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Paradoxical activation of chronic lymphocytic leukemia cells by ruxolitinib in vitro and in vivo
INTRODUCTION: Chronic lymphocytic leukemia (CLL) is characterized by an aberrant cytokine network that can support tumor growth by triggering janus kinase (JAK)/STAT pathways. Targeting cytokine-signaling should then be a rational therapeutic strategy but the JAK inhibitor ruxolitinib failed to cont...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126367/ https://www.ncbi.nlm.nih.gov/pubmed/37114129 http://dx.doi.org/10.3389/fonc.2023.1043694 |