Use of physiological based pharmacokinetic modeling for cross-species prediction of pharmacokinetic and tissue distribution profiles of a novel niclosamide prodrug

Introduction: Niclosamide (Nc) is an FDA-approved anthelmintic drug that was recently identified in a drug repurposing screening to possess antiviral activity against SARS-CoV-2. However, due to the low solubility and permeability of Nc, its in vivo efficacy was limited by its poor oral absorption....

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Detalles Bibliográficos
Autores principales: Yang, Mengbi, Wang, Amy Q., Padilha, Elias C., Shah, Pranav, Hagen, Natalie R., Ryu, China, Shamim, Khalida, Huang, Wenwei, Xu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126473/
https://www.ncbi.nlm.nih.gov/pubmed/37113753
http://dx.doi.org/10.3389/fphar.2023.1099425

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