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Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer
Epidermal growth factor receptor (EGFR) mutations are common driver genes in nonsmall-cell lung cancer and have different sensitivities to EGFR-tyrosine kinase inhibitors (EGFR-TKIs). EGFR is divided into classic mutations and rare mutations. Classic mutations are well known, but the understanding o...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126640/ https://www.ncbi.nlm.nih.gov/pubmed/37078129 http://dx.doi.org/10.1177/15330338231168466 |
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author | Yu, Limeng Wang, Ruilin Zhao, Yuhua Wu, Yingxi Wang, Lili Chen, Haiyang He, Zhen Wang, Qiming Wu, Yufeng |
author_facet | Yu, Limeng Wang, Ruilin Zhao, Yuhua Wu, Yingxi Wang, Lili Chen, Haiyang He, Zhen Wang, Qiming Wu, Yufeng |
author_sort | Yu, Limeng |
collection | PubMed |
description | Epidermal growth factor receptor (EGFR) mutations are common driver genes in nonsmall-cell lung cancer and have different sensitivities to EGFR-tyrosine kinase inhibitors (EGFR-TKIs). EGFR is divided into classic mutations and rare mutations. Classic mutations are well known, but the understanding of rare mutations is not sufficient. In this article, we summarize the clinical research and treatment progress of rare mutations for different EGFR-TKIs and provide a basis for clinical treatment decisions. |
format | Online Article Text |
id | pubmed-10126640 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-101266402023-04-26 Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer Yu, Limeng Wang, Ruilin Zhao, Yuhua Wu, Yingxi Wang, Lili Chen, Haiyang He, Zhen Wang, Qiming Wu, Yufeng Technol Cancer Res Treat Screening, Diagnosis, and Treatment of Lung Cancer Epidermal growth factor receptor (EGFR) mutations are common driver genes in nonsmall-cell lung cancer and have different sensitivities to EGFR-tyrosine kinase inhibitors (EGFR-TKIs). EGFR is divided into classic mutations and rare mutations. Classic mutations are well known, but the understanding of rare mutations is not sufficient. In this article, we summarize the clinical research and treatment progress of rare mutations for different EGFR-TKIs and provide a basis for clinical treatment decisions. SAGE Publications 2023-04-19 /pmc/articles/PMC10126640/ /pubmed/37078129 http://dx.doi.org/10.1177/15330338231168466 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Screening, Diagnosis, and Treatment of Lung Cancer Yu, Limeng Wang, Ruilin Zhao, Yuhua Wu, Yingxi Wang, Lili Chen, Haiyang He, Zhen Wang, Qiming Wu, Yufeng Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer |
title | Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer |
title_full | Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer |
title_fullStr | Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer |
title_full_unstemmed | Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer |
title_short | Advances in the Treatment of Rare Epidermal Growth Factor Receptor Mutations in Advanced Nonsmall-Cell Lung Cancer |
title_sort | advances in the treatment of rare epidermal growth factor receptor mutations in advanced nonsmall-cell lung cancer |
topic | Screening, Diagnosis, and Treatment of Lung Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126640/ https://www.ncbi.nlm.nih.gov/pubmed/37078129 http://dx.doi.org/10.1177/15330338231168466 |
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