Cargando…

Oocyte aging in comparison to stem cells in mice

To maintain homeostasis, many tissues contain stem cells that can self-renew and differentiate. Based on these functions, stem cells can reconstitute the tissue even after injury. In reproductive organs, testes have spermatogonial stem cells that generate sperm in men throughout their lifetime. Howe...

Descripción completa

Detalles Bibliográficos
Autor principal: Nagamatsu, Go
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126682/
https://www.ncbi.nlm.nih.gov/pubmed/37114094
http://dx.doi.org/10.3389/fragi.2023.1158510
_version_ 1785030309568315392
author Nagamatsu, Go
author_facet Nagamatsu, Go
author_sort Nagamatsu, Go
collection PubMed
description To maintain homeostasis, many tissues contain stem cells that can self-renew and differentiate. Based on these functions, stem cells can reconstitute the tissue even after injury. In reproductive organs, testes have spermatogonial stem cells that generate sperm in men throughout their lifetime. However, in the ovary, oocytes enter meiosis at the embryonic stage and maintain sustainable oogenesis in the absence of stem cells. After birth, oocytes are maintained in a dormant state in the primordial follicle, which is the most premature follicle in the ovary, and some are activated to form mature oocytes. Thus, regulation of dormancy and activation of primordial follicles is critical for a sustainable ovulatory cycle and is directly related to the female reproductive cycle. However, oocyte storage is insufficient to maintain a lifelong ovulation cycle. Therefore, the ovary is one of the earliest organs to be involved in aging. Although stem cells are capable of proliferation, they typically exhibit slow cycling or dormancy. Therefore, there are some supposed similarities with oocytes in primordial follicles, not only in their steady state but also during aging. This review aims to summarise the sustainability of oogenesis and aging phenotypes compared to tissue stem cells. Finally, it focuses on the recent breakthroughs in vitro culture and discusses future prospects.
format Online
Article
Text
id pubmed-10126682
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-101266822023-04-26 Oocyte aging in comparison to stem cells in mice Nagamatsu, Go Front Aging Aging To maintain homeostasis, many tissues contain stem cells that can self-renew and differentiate. Based on these functions, stem cells can reconstitute the tissue even after injury. In reproductive organs, testes have spermatogonial stem cells that generate sperm in men throughout their lifetime. However, in the ovary, oocytes enter meiosis at the embryonic stage and maintain sustainable oogenesis in the absence of stem cells. After birth, oocytes are maintained in a dormant state in the primordial follicle, which is the most premature follicle in the ovary, and some are activated to form mature oocytes. Thus, regulation of dormancy and activation of primordial follicles is critical for a sustainable ovulatory cycle and is directly related to the female reproductive cycle. However, oocyte storage is insufficient to maintain a lifelong ovulation cycle. Therefore, the ovary is one of the earliest organs to be involved in aging. Although stem cells are capable of proliferation, they typically exhibit slow cycling or dormancy. Therefore, there are some supposed similarities with oocytes in primordial follicles, not only in their steady state but also during aging. This review aims to summarise the sustainability of oogenesis and aging phenotypes compared to tissue stem cells. Finally, it focuses on the recent breakthroughs in vitro culture and discusses future prospects. Frontiers Media S.A. 2023-04-11 /pmc/articles/PMC10126682/ /pubmed/37114094 http://dx.doi.org/10.3389/fragi.2023.1158510 Text en Copyright © 2023 Nagamatsu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Aging
Nagamatsu, Go
Oocyte aging in comparison to stem cells in mice
title Oocyte aging in comparison to stem cells in mice
title_full Oocyte aging in comparison to stem cells in mice
title_fullStr Oocyte aging in comparison to stem cells in mice
title_full_unstemmed Oocyte aging in comparison to stem cells in mice
title_short Oocyte aging in comparison to stem cells in mice
title_sort oocyte aging in comparison to stem cells in mice
topic Aging
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126682/
https://www.ncbi.nlm.nih.gov/pubmed/37114094
http://dx.doi.org/10.3389/fragi.2023.1158510
work_keys_str_mv AT nagamatsugo oocyteagingincomparisontostemcellsinmice