An atypical presentation of granulomatosis with polyangiitis: A case report

Granulomatosis with polyangiitis (GPA) is a systemic vasculitis that is associated with antineutrophil cytoplasmic antibodies (c-ANCA). It classically presents with sinonasal, pulmonary and renal involvement. We are presenting a case of a 32-year-old male who presented with septal perforation, crust...

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Autores principales: Maqbool, Umar, Maqbool, Abdullah, Maqbool, Ayesha, Qadeer, Ahsan, Mehmood, Muhammad Fayzan, Loon, Muaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126852/
https://www.ncbi.nlm.nih.gov/pubmed/37113631
http://dx.doi.org/10.1016/j.radcr.2023.03.023
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author Maqbool, Umar
Maqbool, Abdullah
Maqbool, Ayesha
Qadeer, Ahsan
Mehmood, Muhammad Fayzan
Loon, Muaz
author_facet Maqbool, Umar
Maqbool, Abdullah
Maqbool, Ayesha
Qadeer, Ahsan
Mehmood, Muhammad Fayzan
Loon, Muaz
author_sort Maqbool, Umar
collection PubMed
description Granulomatosis with polyangiitis (GPA) is a systemic vasculitis that is associated with antineutrophil cytoplasmic antibodies (c-ANCA). It classically presents with sinonasal, pulmonary and renal involvement. We are presenting a case of a 32-year-old male who presented with septal perforation, crusting and nasal obstruction. He had been operated on twice for sinonasal polyposis. Relevant investigations revealed that he was actually suffering from GPA. The patient was started on remission induction therapy. A combination of methotrexate and prednisolone was started with a 2-weekly follow-up. The patient had experienced his symptoms for 2 years before presentation. This case highlights the importance of correlating ENT and pulmonary symptoms to reach the correct diagnosis.
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spelling pubmed-101268522023-04-26 An atypical presentation of granulomatosis with polyangiitis: A case report Maqbool, Umar Maqbool, Abdullah Maqbool, Ayesha Qadeer, Ahsan Mehmood, Muhammad Fayzan Loon, Muaz Radiol Case Rep Case Report Granulomatosis with polyangiitis (GPA) is a systemic vasculitis that is associated with antineutrophil cytoplasmic antibodies (c-ANCA). It classically presents with sinonasal, pulmonary and renal involvement. We are presenting a case of a 32-year-old male who presented with septal perforation, crusting and nasal obstruction. He had been operated on twice for sinonasal polyposis. Relevant investigations revealed that he was actually suffering from GPA. The patient was started on remission induction therapy. A combination of methotrexate and prednisolone was started with a 2-weekly follow-up. The patient had experienced his symptoms for 2 years before presentation. This case highlights the importance of correlating ENT and pulmonary symptoms to reach the correct diagnosis. Elsevier 2023-04-14 /pmc/articles/PMC10126852/ /pubmed/37113631 http://dx.doi.org/10.1016/j.radcr.2023.03.023 Text en © 2023 The Authors. Published by Elsevier Inc. on behalf of University of Washington. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Maqbool, Umar
Maqbool, Abdullah
Maqbool, Ayesha
Qadeer, Ahsan
Mehmood, Muhammad Fayzan
Loon, Muaz
An atypical presentation of granulomatosis with polyangiitis: A case report
title An atypical presentation of granulomatosis with polyangiitis: A case report
title_full An atypical presentation of granulomatosis with polyangiitis: A case report
title_fullStr An atypical presentation of granulomatosis with polyangiitis: A case report
title_full_unstemmed An atypical presentation of granulomatosis with polyangiitis: A case report
title_short An atypical presentation of granulomatosis with polyangiitis: A case report
title_sort atypical presentation of granulomatosis with polyangiitis: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10126852/
https://www.ncbi.nlm.nih.gov/pubmed/37113631
http://dx.doi.org/10.1016/j.radcr.2023.03.023
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