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Understanding antimicrobial susceptibility profile of Finegoldia magna: an insight to an untrodden path
BACKGROUND: Finegoldia magna (formerly known as Peptococcus magnus or Peptostreptococcus magnus) belonging to phylum Firmicutes, class Clostridia and genus Finegoldia, is the only species known to cause infections in human beings. Amongst Gram positive anaerobic cocci, F. magna is known to be the mo...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127037/ https://www.ncbi.nlm.nih.gov/pubmed/37098571 http://dx.doi.org/10.1186/s12941-023-00583-1 |
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author | Shetty, Seema Anegundi, Renuka Shenoy, Padmaja Ananth Vishwanath, Shashidhar |
author_facet | Shetty, Seema Anegundi, Renuka Shenoy, Padmaja Ananth Vishwanath, Shashidhar |
author_sort | Shetty, Seema |
collection | PubMed |
description | BACKGROUND: Finegoldia magna (formerly known as Peptococcus magnus or Peptostreptococcus magnus) belonging to phylum Firmicutes, class Clostridia and genus Finegoldia, is the only species known to cause infections in human beings. Amongst Gram positive anaerobic cocci, F. magna is known to be the most virulent with a high pathogenic potential. Significant upsurge in antimicrobial resistance among anaerobes has been documented by various studies. F. magna is known to be susceptible to most of the anti-anaerobic antimicrobials, however, multidrug resistant strains are being reported in literature. The present study was undertaken to highlight the role of F. magna in clinical infections and to analyze their antimicrobial susceptibility patterns. METHODS: The present study was conducted in a tertiary care teaching hospital in Southern India. 42 clinical isolates of F. magna recovered from diverse clinical infections between January 2011 to December 2015 were studied. These isolates were subjected to antimicrobial susceptibility testing against metronidazole, clindamycin, cefoxitin, penicillin, chloramphenicol and linezolid. RESULTS: Among the 42 isolates studied, majority of them were revived from diabetic foot infections (31%) followed by necrotizing fasciitis (19%) and deep-seated abscesses (19%). All the F. magna isolates showed good in-vitro activity against metronidazole, cefoxitin, linezolid and chloramphenicol. Clindamycin and penicillin resistance were observed against 9.5% and 2.4% of the isolates respectively. However, β-lactamase activity was not detected. CONCLUSION: The antimicrobial resistance among anaerobes varies from pathogen to pathogen and region to region. Hence, a deep understanding of resistance pattern is necessary for better management of clinical infections. |
format | Online Article Text |
id | pubmed-10127037 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-101270372023-04-26 Understanding antimicrobial susceptibility profile of Finegoldia magna: an insight to an untrodden path Shetty, Seema Anegundi, Renuka Shenoy, Padmaja Ananth Vishwanath, Shashidhar Ann Clin Microbiol Antimicrob Research BACKGROUND: Finegoldia magna (formerly known as Peptococcus magnus or Peptostreptococcus magnus) belonging to phylum Firmicutes, class Clostridia and genus Finegoldia, is the only species known to cause infections in human beings. Amongst Gram positive anaerobic cocci, F. magna is known to be the most virulent with a high pathogenic potential. Significant upsurge in antimicrobial resistance among anaerobes has been documented by various studies. F. magna is known to be susceptible to most of the anti-anaerobic antimicrobials, however, multidrug resistant strains are being reported in literature. The present study was undertaken to highlight the role of F. magna in clinical infections and to analyze their antimicrobial susceptibility patterns. METHODS: The present study was conducted in a tertiary care teaching hospital in Southern India. 42 clinical isolates of F. magna recovered from diverse clinical infections between January 2011 to December 2015 were studied. These isolates were subjected to antimicrobial susceptibility testing against metronidazole, clindamycin, cefoxitin, penicillin, chloramphenicol and linezolid. RESULTS: Among the 42 isolates studied, majority of them were revived from diabetic foot infections (31%) followed by necrotizing fasciitis (19%) and deep-seated abscesses (19%). All the F. magna isolates showed good in-vitro activity against metronidazole, cefoxitin, linezolid and chloramphenicol. Clindamycin and penicillin resistance were observed against 9.5% and 2.4% of the isolates respectively. However, β-lactamase activity was not detected. CONCLUSION: The antimicrobial resistance among anaerobes varies from pathogen to pathogen and region to region. Hence, a deep understanding of resistance pattern is necessary for better management of clinical infections. BioMed Central 2023-04-25 /pmc/articles/PMC10127037/ /pubmed/37098571 http://dx.doi.org/10.1186/s12941-023-00583-1 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Shetty, Seema Anegundi, Renuka Shenoy, Padmaja Ananth Vishwanath, Shashidhar Understanding antimicrobial susceptibility profile of Finegoldia magna: an insight to an untrodden path |
title | Understanding antimicrobial susceptibility profile of Finegoldia magna: an insight to an untrodden path |
title_full | Understanding antimicrobial susceptibility profile of Finegoldia magna: an insight to an untrodden path |
title_fullStr | Understanding antimicrobial susceptibility profile of Finegoldia magna: an insight to an untrodden path |
title_full_unstemmed | Understanding antimicrobial susceptibility profile of Finegoldia magna: an insight to an untrodden path |
title_short | Understanding antimicrobial susceptibility profile of Finegoldia magna: an insight to an untrodden path |
title_sort | understanding antimicrobial susceptibility profile of finegoldia magna: an insight to an untrodden path |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127037/ https://www.ncbi.nlm.nih.gov/pubmed/37098571 http://dx.doi.org/10.1186/s12941-023-00583-1 |
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