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Inflammatory markers in children with obstructive sleep apnea syndrome

OBJECTIVE: To evaluate serum inflammatory markers of YKL-40, Interleukin-6 (IL-6), Interleukin-8(IL-8), Interleukin-10(IL-10), TNF-α(tumor necrosis factor-α), and CRP (C-reactive protein) in children with and without OSAS. METHODS: The ELISA technique has been used to identify the concentration of i...

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Autores principales: Wang, Yingge, Chen, Ying, Lin, Wei, Huang, Min, Xu, Yuanteng, Chen, Guohao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127118/
https://www.ncbi.nlm.nih.gov/pubmed/37114011
http://dx.doi.org/10.3389/fped.2023.1134678
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author Wang, Yingge
Chen, Ying
Lin, Wei
Huang, Min
Xu, Yuanteng
Chen, Guohao
author_facet Wang, Yingge
Chen, Ying
Lin, Wei
Huang, Min
Xu, Yuanteng
Chen, Guohao
author_sort Wang, Yingge
collection PubMed
description OBJECTIVE: To evaluate serum inflammatory markers of YKL-40, Interleukin-6 (IL-6), Interleukin-8(IL-8), Interleukin-10(IL-10), TNF-α(tumor necrosis factor-α), and CRP (C-reactive protein) in children with and without OSAS. METHODS: The ELISA technique has been used to identify the concentration of inflammatory markers such as YKL-40, IL-6, IL-8, IL-10, TNF-α, and CRP in the serum of 83 children with OSAS and 83 children without OSAS. RESULTS: Serum levels of YKL-40, IL-6, IL-8, and IL-10 were found to be increased in children with OSAS. YKL-40 was found to be positively correlated with IL-6 and IL-8, and negatively correlated with IL-10. At the same time,YKL-40 was also found to be positively correlated with OAHI and LoSpO2% in OSAS group. IL-8 was positively correlated with OAHI whereas IL-10 was positively correlated with LoSpO2. CONCLUSION: Children with OSAS are in a systemic inflammatory state. YKL-40 together with IL-8 may act as serum inflammatory markers and provide an indication for the diagnosis of children with OSAS.
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spelling pubmed-101271182023-04-26 Inflammatory markers in children with obstructive sleep apnea syndrome Wang, Yingge Chen, Ying Lin, Wei Huang, Min Xu, Yuanteng Chen, Guohao Front Pediatr Pediatrics OBJECTIVE: To evaluate serum inflammatory markers of YKL-40, Interleukin-6 (IL-6), Interleukin-8(IL-8), Interleukin-10(IL-10), TNF-α(tumor necrosis factor-α), and CRP (C-reactive protein) in children with and without OSAS. METHODS: The ELISA technique has been used to identify the concentration of inflammatory markers such as YKL-40, IL-6, IL-8, IL-10, TNF-α, and CRP in the serum of 83 children with OSAS and 83 children without OSAS. RESULTS: Serum levels of YKL-40, IL-6, IL-8, and IL-10 were found to be increased in children with OSAS. YKL-40 was found to be positively correlated with IL-6 and IL-8, and negatively correlated with IL-10. At the same time,YKL-40 was also found to be positively correlated with OAHI and LoSpO2% in OSAS group. IL-8 was positively correlated with OAHI whereas IL-10 was positively correlated with LoSpO2. CONCLUSION: Children with OSAS are in a systemic inflammatory state. YKL-40 together with IL-8 may act as serum inflammatory markers and provide an indication for the diagnosis of children with OSAS. Frontiers Media S.A. 2023-04-11 /pmc/articles/PMC10127118/ /pubmed/37114011 http://dx.doi.org/10.3389/fped.2023.1134678 Text en © 2023 Wang, Chen, Lin, Huang, Xu, and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pediatrics
Wang, Yingge
Chen, Ying
Lin, Wei
Huang, Min
Xu, Yuanteng
Chen, Guohao
Inflammatory markers in children with obstructive sleep apnea syndrome
title Inflammatory markers in children with obstructive sleep apnea syndrome
title_full Inflammatory markers in children with obstructive sleep apnea syndrome
title_fullStr Inflammatory markers in children with obstructive sleep apnea syndrome
title_full_unstemmed Inflammatory markers in children with obstructive sleep apnea syndrome
title_short Inflammatory markers in children with obstructive sleep apnea syndrome
title_sort inflammatory markers in children with obstructive sleep apnea syndrome
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127118/
https://www.ncbi.nlm.nih.gov/pubmed/37114011
http://dx.doi.org/10.3389/fped.2023.1134678
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