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Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering

Albumin is derived from blood plasma and is the most abundant protein in blood plasma, which has good mechanical properties, biocompatibility and degradability, so albumin is an ideal biomaterial for biomedical applications, and drug-carriers based on albumin can better reduce the cytotoxicity of dr...

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Autores principales: Meng, Run, Zhu, Huimin, Deng, Peiying, Li, Minghui, Ji, Qingzhi, He, Hao, Jin, Liang, Wang, Bochu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127125/
https://www.ncbi.nlm.nih.gov/pubmed/37113668
http://dx.doi.org/10.3389/fbioe.2023.1137145
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author Meng, Run
Zhu, Huimin
Deng, Peiying
Li, Minghui
Ji, Qingzhi
He, Hao
Jin, Liang
Wang, Bochu
author_facet Meng, Run
Zhu, Huimin
Deng, Peiying
Li, Minghui
Ji, Qingzhi
He, Hao
Jin, Liang
Wang, Bochu
author_sort Meng, Run
collection PubMed
description Albumin is derived from blood plasma and is the most abundant protein in blood plasma, which has good mechanical properties, biocompatibility and degradability, so albumin is an ideal biomaterial for biomedical applications, and drug-carriers based on albumin can better reduce the cytotoxicity of drug. Currently, there are numerous reviews summarizing the research progress on drug-loaded albumin molecules or nanoparticles. In comparison, the study of albumin-based hydrogels is a relatively small area of research, and few articles have systematically summarized the research progress of albumin-based hydrogels, especially for drug delivery and tissue engineering. Thus, this review summarizes the functional features and preparation methods of albumin-based hydrogels, different types of albumin-based hydrogels and their applications in antitumor drugs, tissue regeneration engineering, etc. Also, potential directions for future research on albumin-based hydrogels are discussed.
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spelling pubmed-101271252023-04-26 Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering Meng, Run Zhu, Huimin Deng, Peiying Li, Minghui Ji, Qingzhi He, Hao Jin, Liang Wang, Bochu Front Bioeng Biotechnol Bioengineering and Biotechnology Albumin is derived from blood plasma and is the most abundant protein in blood plasma, which has good mechanical properties, biocompatibility and degradability, so albumin is an ideal biomaterial for biomedical applications, and drug-carriers based on albumin can better reduce the cytotoxicity of drug. Currently, there are numerous reviews summarizing the research progress on drug-loaded albumin molecules or nanoparticles. In comparison, the study of albumin-based hydrogels is a relatively small area of research, and few articles have systematically summarized the research progress of albumin-based hydrogels, especially for drug delivery and tissue engineering. Thus, this review summarizes the functional features and preparation methods of albumin-based hydrogels, different types of albumin-based hydrogels and their applications in antitumor drugs, tissue regeneration engineering, etc. Also, potential directions for future research on albumin-based hydrogels are discussed. Frontiers Media S.A. 2023-04-11 /pmc/articles/PMC10127125/ /pubmed/37113668 http://dx.doi.org/10.3389/fbioe.2023.1137145 Text en Copyright © 2023 Meng, Zhu, Deng, Li, Ji, He, Jin and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Meng, Run
Zhu, Huimin
Deng, Peiying
Li, Minghui
Ji, Qingzhi
He, Hao
Jin, Liang
Wang, Bochu
Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering
title Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering
title_full Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering
title_fullStr Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering
title_full_unstemmed Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering
title_short Research progress on albumin-based hydrogels: Properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering
title_sort research progress on albumin-based hydrogels: properties, preparation methods, types and its application for antitumor-drug delivery and tissue engineering
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127125/
https://www.ncbi.nlm.nih.gov/pubmed/37113668
http://dx.doi.org/10.3389/fbioe.2023.1137145
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