Cargando…

Loss of BLK expression as a potential predictor of poor prognosis and immune checkpoint blockade response in NSCLC and contribute to tumor progression

BACKGROUND: Immune checkpoint blockade (ICB) has been proved to have significant anti-tumor effect in the clinical treatment of non-small cell lung cancer (NSCLC). Therefore, biomarkers predicting ICB response can provide better treatment for patients with NSCLC. METHODS: Differential expression gen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Yingqi, Xu, Jianlin, Qiao, Rong, Zhong, Hua, Xia, Jinjing, Zhong, Runbo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127141/ https://www.ncbi.nlm.nih.gov/pubmed/37068401 http://dx.doi.org/10.1016/j.tranon.2023.101671

Ejemplares similares

Comparative efficacy and safety of multitarget angiogenesis inhibitor combined with immune checkpoint inhibitor and nivolumab monotherapy as second-line or beyond for advanced lung adenocarcinoma in driver-negative patients: a retrospective comparative cohort study
por: Yu, Lian, et al.
Publicado: (2023)

The Src-Family Kinases SRC and BLK Contribute to the CLDN6-Adhesion Signaling
por: Ichikawa-Tomikawa, Naoki, et al.
Publicado: (2023)

Detection of Genetic Mutations by Next-Generation Sequencing for Predicting Prognosis of Extensive-Stage Small-Cell Lung Cancer
por: Chen, Dongfang, et al.
Publicado: (2020)

Functional rare and low frequency variants in BLK and BANK1 contribute to human lupus
por: Jiang, Simon H., et al.
Publicado: (2019)

Association Between Obesity and Poor Prognosis in Patients Receiving Anlotinib for Advanced Non-Small Cell Lung Cancer
por: Xiong, Anning, et al.
Publicado: (2022)

Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein
por: Delgado-Vega, Angélica M, et al.
Publicado: (2012)

Patterns of Recurrence and Survival Rate After Complete Resection of Pathological Stage N2 Small-Cell Lung Cancer
por: Yu, Lian, et al.
Publicado: (2021)

Efficacy and safety of anlotinib combined with PD‐1/PD‐L1 inhibitors as second‐line and subsequent therapy in advanced small‐cell lung cancer
por: Yu, Lian, et al.
Publicado: (2022)

Immune Checkpoint Blockade for Advanced NSCLC: A New Landscape for Elderly Patients
por: Perrotta, Fabio, et al.
Publicado: (2019)

BLK polymorphisms and expression level in neuromyelitis optica spectrum disorder
por: Yin, Bo‐Wen, et al.
Publicado: (2021)

Association of PTPRD/PTPRT Mutation With Better Clinical Outcomes in NSCLC Patients Treated With Immune Checkpoint Blockades
por: Wang, Xiaoyan, et al.
Publicado: (2021)

Predictors of responses to immune checkpoint blockade in advanced melanoma
por: Jacquelot, N., et al.
Publicado: (2017)

Metabolic predictors of response to immune checkpoint blockade therapy
por: Shorer, Ofir, et al.
Publicado: (2023)

Tyrosine phosphorylation of IRF3 by BLK facilitates its sufficient activation and innate antiviral response
por: Li, Wei-Wei, et al.
Publicado: (2023)

Clinical outcomes of immune checkpoint blockades and the underlying immune escape mechanisms in squamous and adenocarcinoma NSCLC
por: Tian, Yaru, et al.
Publicado: (2020)

Mimicry of Pre–B Cell Receptor Signaling by Activation of the Tyrosine Kinase Blk
por: Tretter, Theresa, et al.
Publicado: (2003)

The Effect of Inversion at 8p23 on BLK Association with Lupus in Caucasian Population
por: Namjou, Bahram, et al.
Publicado: (2014)

Association between TNFSF4 and BLK gene polymorphisms and susceptibility to allergic rhinitis
por: Shen, Yang, et al.
Publicado: (2017)

PIG3 promotes NSCLC cell mitotic progression and is associated with poor prognosis of NSCLC patients
por: Li, Ming, et al.
Publicado: (2017)

The Blk pathway functions as a tumor suppressor in chronic myeloid leukemia stem cells
por: Zhang, Haojian, et al.
Publicado: (2012)

IgA Vasculitis: Influence of CD40, BLK and BANK1 Gene Polymorphisms
por: Batista Liz, Joao Carlos, et al.
Publicado: (2022)

Osimertinib alone as second-line treatment for brain metastases (BM) control may be more limited than for non-BM in advanced NSCLC patients with an acquired EGFR T790M mutation
por: Li, Changhui, et al.
Publicado: (2021)

Genomic alteration of MTAP/CDKN2A predicts sarcomatoid differentiation and poor prognosis and modulates response to immune checkpoint blockade in renal cell carcinoma
por: Xu, Wenhao, et al.
Publicado: (2022)

Neutrophil–lymphocyte ratio (NLR) predicted prognosis for advanced non-small-cell lung cancer (NSCLC) patients who received immune checkpoint blockade (ICB)
por: Ren, Fangping, et al.
Publicado: (2019)

CCND1 Amplification Contributes to Immunosuppression and Is Associated With a Poor Prognosis to Immune Checkpoint Inhibitors in Solid Tumors
por: Chen, Yu, et al.
Publicado: (2020)

Machine Learning Predictor of Immune Checkpoint Blockade Response in Gastric Cancer
por: Sung, Ji-Yong, et al.
Publicado: (2022)

SERPINB9 is commonly amplified and high expression in cancer cells correlates with poor immune checkpoint blockade response
por: Ibáñez-Molero, Sofía, et al.
Publicado: (2022)

BANK1 and BLK Act through Phospholipase C Gamma 2 in B-Cell Signaling
por: Bernal-Quirós, Manuel, et al.
Publicado: (2013)

Assessment of the Clinical Heterogeneity of Kawasaki Disease Using Genetic Variants of BLK and FCGR2A
por: Sim, Bo Kyung, et al.
Publicado: (2018)

Association of BLK and BANK1 Polymorphisms and Interactions With Rheumatoid Arthritis in a Latin-American Population
por: Ramírez-Bello, Julian, et al.
Publicado: (2020)

Combined Single Nucleotide Variants of ORAI1 and BLK in a Child with Refractory Kawasaki Disease
por: Kanda, Saki, et al.
Publicado: (2021)

Prognostic significance of BLK expression in R-CHOP treated diffuse large B-cell lymphoma
por: Choi, Soyeon, et al.
Publicado: (2022)

Inhibition of glycolysis-driven immunosuppression with a nano-assembly enhances response to immune checkpoint blockade therapy in triple negative breast cancer
por: Ren, Xijiao, et al.
Publicado: (2023)

Does surgically resected small‐cell lung cancer without lymph node involvement benefit from prophylactic cranial irradiation?
por: Lou, Yuqing, et al.
Publicado: (2020)

CDCA8 as an independent predictor for a poor prognosis in liver cancer
por: Shuai, Yu, et al.
Publicado: (2021)

TLR9 activation cooperates with T cell checkpoint blockade to regress poorly immunogenic melanoma
por: Reilley, Matthew J., et al.
Publicado: (2019)

KRAS mutation is a weak, but valid predictor for poor prognosis and treatment outcomes in NSCLC: A meta-analysis of 41 studies
por: Pan, Wei, et al.
Publicado: (2016)

Predictive value of PIMREG in the prognosis and response to immune checkpoint blockade of glioma patients
por: Zhu, Hua, et al.
Publicado: (2022)

Insignificant effects of loss of heterozygosity in HLA in the efficacy of immune checkpoint blockade treatment
por: Yang, Yohan, et al.
Publicado: (2022)

SAT081 Maturity Onset Diabetes Of The Young (MODY) Due To A New BLK Gene Mutation
por: Taha, Doris, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_pd6oomlljfgo3d9salvf2mmtia