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The importance of quarantine: modelling the COVID-19 testing process

We incorporate the disease state and testing state into the formulation of a COVID-19 epidemic model. For this model, the basic reproduction number is identified and its dependence on model parameters related to the testing process and isolation efficacy is discussed. The relations between the basic...

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Autores principales: Xu, Wanxiao, Shu, Hongying, Wang, Lin, Wang, Xiang-Sheng, Watmough, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127192/
https://www.ncbi.nlm.nih.gov/pubmed/37097481
http://dx.doi.org/10.1007/s00285-023-01916-6
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author Xu, Wanxiao
Shu, Hongying
Wang, Lin
Wang, Xiang-Sheng
Watmough, James
author_facet Xu, Wanxiao
Shu, Hongying
Wang, Lin
Wang, Xiang-Sheng
Watmough, James
author_sort Xu, Wanxiao
collection PubMed
description We incorporate the disease state and testing state into the formulation of a COVID-19 epidemic model. For this model, the basic reproduction number is identified and its dependence on model parameters related to the testing process and isolation efficacy is discussed. The relations between the basic reproduction number, the final epidemic and peak sizes, and the model parameters are further explored numerically. We find that fast test reporting does not always benefit the control of the COVID-19 epidemic if good quarantine while awaiting test results is implemented. Moreover, the final epidemic and peak sizes do not always increase along with the basic reproduction number. Under some circumstances, lowering the basic reproduction number increases the final epidemic and peak sizes. Our findings suggest that properly implementing isolation for individuals who are waiting for their testing results would lower the basic reproduction number as well as the final epidemic and peak sizes.
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spelling pubmed-101271922023-04-27 The importance of quarantine: modelling the COVID-19 testing process Xu, Wanxiao Shu, Hongying Wang, Lin Wang, Xiang-Sheng Watmough, James J Math Biol Article We incorporate the disease state and testing state into the formulation of a COVID-19 epidemic model. For this model, the basic reproduction number is identified and its dependence on model parameters related to the testing process and isolation efficacy is discussed. The relations between the basic reproduction number, the final epidemic and peak sizes, and the model parameters are further explored numerically. We find that fast test reporting does not always benefit the control of the COVID-19 epidemic if good quarantine while awaiting test results is implemented. Moreover, the final epidemic and peak sizes do not always increase along with the basic reproduction number. Under some circumstances, lowering the basic reproduction number increases the final epidemic and peak sizes. Our findings suggest that properly implementing isolation for individuals who are waiting for their testing results would lower the basic reproduction number as well as the final epidemic and peak sizes. Springer Berlin Heidelberg 2023-04-25 2023 /pmc/articles/PMC10127192/ /pubmed/37097481 http://dx.doi.org/10.1007/s00285-023-01916-6 Text en © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Xu, Wanxiao
Shu, Hongying
Wang, Lin
Wang, Xiang-Sheng
Watmough, James
The importance of quarantine: modelling the COVID-19 testing process
title The importance of quarantine: modelling the COVID-19 testing process
title_full The importance of quarantine: modelling the COVID-19 testing process
title_fullStr The importance of quarantine: modelling the COVID-19 testing process
title_full_unstemmed The importance of quarantine: modelling the COVID-19 testing process
title_short The importance of quarantine: modelling the COVID-19 testing process
title_sort importance of quarantine: modelling the covid-19 testing process
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127192/
https://www.ncbi.nlm.nih.gov/pubmed/37097481
http://dx.doi.org/10.1007/s00285-023-01916-6
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