Capturing Differences in the Regulation of LRRK2 Dynamics and Conformational States by Small Molecule Kinase Inhibitors

[Image: see text] Mutations in the human leucine rich repeat protein kinase-2 (LRRK2) create risk factors for Parkinson’s disease, and pathological functions of LRRK2 are often correlated with aberrant kinase activity. Past research has focused on developing selective LRRK2 kinase inhibitors. In thi...

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Detalles Bibliográficos
Autores principales: Weng, Jui-Hung, Ma, Wen, Wu, Jian, Sharma, Pallavi Kaila, Silletti, Steve, McCammon, J. Andrew, Taylor, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127209/
https://www.ncbi.nlm.nih.gov/pubmed/37043829
http://dx.doi.org/10.1021/acschembio.2c00868

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