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Electronegative clusters modulate folding status and RNA binding of unstructured RNA‐binding proteins

Electronegative clusters (ENCs) made up of acidic residues and/or phosphorylation sites are the most abundant repetitive sequences in RNA‐binding proteins. Previous studies have indicated that ENCs inhibit RNA binding for structured RNA‐binding domains (RBDs). However, this is not the case for the u...

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Detalles Bibliográficos
Autores principales: Zaharias, Steve, Fargason, Talia, Greer, Rory, Song, Yuhua, Zhang, Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127258/
https://www.ncbi.nlm.nih.gov/pubmed/37060324
http://dx.doi.org/10.1002/pro.4643