Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity

New analogs of the antiprotozoal agent Furamidine were prepared utilizing Stille coupling reactions and amidation of the bisnitrile intermediate using lithium bis-trimethylsilylamide. Both the phenyl groups and the furan moiety of furamidine were replaced by heterocycles including thiophene, selenop...

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Detalles Bibliográficos
Autores principales: Farahat, Abdelbasset A., Kumar, Arvind, Wenzler, Tanja, Brun, Reto, Paul, Ananya, Guo, Pu, Wilson, W. David, Boykin, David W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editions Scientifiques Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127280/
https://www.ncbi.nlm.nih.gov/pubmed/36958267
http://dx.doi.org/10.1016/j.ejmech.2023.115287

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127280/
https://www.ncbi.nlm.nih.gov/pubmed/36958267
http://dx.doi.org/10.1016/j.ejmech.2023.115287

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