Cargando…

Investigation of the effect of structure modification of furamidine on the DNA minor groove binding and antiprotozoal activity

New analogs of the antiprotozoal agent Furamidine were prepared utilizing Stille coupling reactions and amidation of the bisnitrile intermediate using lithium bis-trimethylsilylamide. Both the phenyl groups and the furan moiety of furamidine were replaced by heterocycles including thiophene, selenop...

Descripción completa

Detalles Bibliográficos
Autores principales:	Farahat, Abdelbasset A., Kumar, Arvind, Wenzler, Tanja, Brun, Reto, Paul, Ananya, Guo, Pu, Wilson, W. David, Boykin, David W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Editions Scientifiques Elsevier 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127280/ https://www.ncbi.nlm.nih.gov/pubmed/36958267 http://dx.doi.org/10.1016/j.ejmech.2023.115287

Ejemplares similares

Thermodynamic Factors That Drive Sequence-Specific DNA Binding of Designed, Synthetic Minor Groove Binding Agents
por: Paul, Ananya, et al.
Publicado: (2022)

Exploration of DAPI analogues: Synthesis, antitrypanosomal activity, DNA binding and fluorescence properties
por: Farahat, Abdelbasset A., et al.
Publicado: (2017)

Indole and Benzimidazole Bichalcophenes: Synthesis, DNA Binding and Antiparasitic Activity
por: Farahat, Abdelbasset A., et al.
Publicado: (2018)

Engineered modular heterocyclic-diamidines for sequence-specific recognition of mixed AT/GC base pairs at the DNA minor groove
por: Guo, Pu, et al.
Publicado: (2021)

A New Generation of Minor-Groove-Binding—Heterocyclic Diamidines That Recognize G·C Base Pairs in an AT Sequence Context
por: Paul, Ananya, et al.
Publicado: (2019)

Large, sequence-dependent effects on DNA conformation by minor groove binding compounds
por: Tevis, Denise S., et al.
Publicado: (2009)

Imino proton NMR guides the reprogramming of A•T specific minor groove binders for mixed base pair recognition
por: Harika, Narinder K., et al.
Publicado: (2016)

Dynamic self-assembly of DNA minor groove-binding ligand DB921 into nanotubes triggered by an alkali halide
por: Mizuta, R., et al.
Publicado: (2018)

Quantitative Structure − Antiprotozoal Activity Relationships of Sesquiterpene Lactones (†)
por: Schmidt, Thomas J., et al.
Publicado: (2009)

X-ray Structure Characterization of the Selective Recognition of AT Base Pair Sequences
por: Ogbonna, Edwin N., et al.
Publicado: (2023)

Antiprotozoal Activity of (E)-Cinnamic N-Acylhydrazone Derivatives
por: Carvalho, Samir Aquino, et al.
Publicado: (2014)

Alkamides from Anacyclus pyrethrum L. and Their in Vitro Antiprotozoal Activity
por: Althaus, Julia B., et al.
Publicado: (2017)

Antiprotozoal Activity of Achillea ptarmica (Asteraceae) and Its Main Alkamide Constituents †
por: Althaus, Julia B., et al.
Publicado: (2014)

The Unusual Monomer Recognition of Guanine-Containing Mixed Sequence DNA by a Dithiophene Heterocyclic Diamidine
por: Munde, Manoj, et al.
Publicado: (2014)

Structure-dependent inhibition of the ETS-family transcription factor PU.1 by novel heterocyclic diamidines
por: Munde, Manoj, et al.
Publicado: (2014)

Complexity in the binding of minor groove agents: netropsin has two thermodynamically different DNA binding modes at a single site
por: Lewis, Edwin A., et al.
Publicado: (2011)

Antiprotozoal Activity Profiling of Approved Drugs: A Starting Point toward Drug Repositioning
por: Kaiser, Marcel, et al.
Publicado: (2015)

Pharmacologic efficacy of PU.1 inhibition by heterocyclic dications: a mechanistic analysis
por: Stephens, Dominique C., et al.
Publicado: (2016)

ent-Pimarane and ent-Kaurane Diterpenes from Aldama discolor (Asteraceae) and Their Antiprotozoal Activity
por: Nogueira, Mauro S., et al.
Publicado: (2016)

HIV chromatin is a preferred target for drugs that bind in the DNA minor groove
por: Collings, Clayton K., et al.
Publicado: (2019)

Search for Antiprotozoal Activity in Herbal Medicinal Preparations; New Natural Leads against Neglected Tropical Diseases
por: Llurba Montesino, Núria, et al.
Publicado: (2015)

Antiprotozoal Effect of Saponins in the Rumen Can Be Enhanced by Chemical Modifications in Their Structure
por: Ramos-Morales, Eva, et al.
Publicado: (2017)

Sustained Release of Minor-Groove-Binding Antibiotic Netropsin from Calcium-Coated Groove-Rich DNA Particles
por: Jeon, Hyunsu, et al.
Publicado: (2019)

What drives the binding of minor groove-directed ligands to DNA hairpins?
por: Lah, Jurij, et al.
Publicado: (2008)

AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes
por: Garabedian, Alyssa, et al.
Publicado: (2022)

Antiprotozoal Drugs
por: Thurston, Scott, et al.
Publicado: (2015)

Electrocardiographic Findings in Acutely and Chronically T. cruzi-infected Mice Treated by a Phenyl-Substituted Analogue of Furamidine DB569
por: de Souza, Elen M., et al.
Publicado: (2007)

Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines
por: Nhili, Raja, et al.
Publicado: (2013)

Coumarin-chalcone hybrid instigates DNA damage by minor groove binding and stabilizes p53 through post translational modifications
por: Ashraf, Raghib, et al.
Publicado: (2017)

Microarray analysis of the in vivo sequence preferences of a minor groove binding drug
por: Eckdahl, Todd T, et al.
Publicado: (2008)

Mechanistic studies on DNA damage by minor groove binding copper–phenanthroline conjugates
por: Bales, Brian C., et al.
Publicado: (2005)

Induced topological changes in DNA complexes: influence of DNA sequences and small molecule structures
por: Hunt, Rebecca A., et al.
Publicado: (2011)

Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
por: Barceló, Francisca, et al.
Publicado: (2007)

Specific minor groove solvation is a crucial determinant of DNA binding site recognition
por: Harris, Lydia-Ann, et al.
Publicado: (2014)

Stabilization of G-Quadruplex-Duplex Hybrid Structures Induced by Minor Groove-Binding Drugs
por: Scott, Lily, et al.
Publicado: (2022)

Delta chirality ruthenium ‘light-switch’ complexes can bind in the minor groove of DNA with five different binding modes
por: Hall, James P., et al.
Publicado: (2016)

Antiprotozoal Activity of Buxus sempervirens and Activity-Guided Isolation of O-tigloylcyclovirobuxeine-B as the Main Constituent Active against Plasmodium falciparum ‡
por: Althaus, Julia B., et al.
Publicado: (2014)

Selective Anti-Leishmanial Strathclyde Minor Groove Binders Using an N-Oxide Tail-Group Modification
por: Perieteanu, Marina C., et al.
Publicado: (2022)

Binding to the Minor Groove of the Double-Strand, Tau Protein Prevents DNA from Damage by Peroxidation
por: Wei, Yan, et al.
Publicado: (2008)

Control of DNA minor groove width and Fis protein binding by the purine 2-amino group
por: Hancock, Stephen P., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_9aibaadonflruu10n55tcfj2ha