Prevalence, causes and impact of TP53-loss phenocopying events in human tumors

BACKGROUND: TP53 is a master tumor suppressor gene, mutated in approximately half of all human cancers. Given the many regulatory roles of the corresponding p53 protein, it is possible to infer loss of p53 activity – which may occur due to alterations in trans – from gene expression patterns. Severa...

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Detalles Bibliográficos
Autores principales: Fito-Lopez, Bruno, Salvadores, Marina, Alvarez, Miguel-Martin, Supek, Fran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127307/
https://www.ncbi.nlm.nih.gov/pubmed/37095494
http://dx.doi.org/10.1186/s12915-023-01595-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127307/
https://www.ncbi.nlm.nih.gov/pubmed/37095494
http://dx.doi.org/10.1186/s12915-023-01595-1

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