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Prevalence, causes and impact of TP53-loss phenocopying events in human tumors
BACKGROUND: TP53 is a master tumor suppressor gene, mutated in approximately half of all human cancers. Given the many regulatory roles of the corresponding p53 protein, it is possible to infer loss of p53 activity – which may occur due to alterations in trans – from gene expression patterns. Severa...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127307/ https://www.ncbi.nlm.nih.gov/pubmed/37095494 http://dx.doi.org/10.1186/s12915-023-01595-1 |