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Breast implant associated EBV-positive Diffuse Large B-cell lymphoma: an underrecognized entity?

Breast-implant associated (BIA) lymphoma is an infrequent type of cancer occurring in the fluid and fibrous capsule around a textured breast implant. Recently, both the 2022 WHO 5th edition classification of Haematological tumours (WHO HAEM5) and 2022 International Consensus Classification of Mature...

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Autores principales: Vets, Johanna, Marcelis, Lukas, Schepers, Charlotte, Dorreman, Yaliva, Verbeek, Sanne, Vanwalleghem, Lieve, Gieraerts, Katrien, Meylaerts, Liesbeth, Lesaffer, Jan, Devos, Helena, Put, Natalie, Snauwaert, Sylvia, De Paepe, Pascale, Tousseyn, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127423/
https://www.ncbi.nlm.nih.gov/pubmed/37098615
http://dx.doi.org/10.1186/s13000-023-01337-5
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author Vets, Johanna
Marcelis, Lukas
Schepers, Charlotte
Dorreman, Yaliva
Verbeek, Sanne
Vanwalleghem, Lieve
Gieraerts, Katrien
Meylaerts, Liesbeth
Lesaffer, Jan
Devos, Helena
Put, Natalie
Snauwaert, Sylvia
De Paepe, Pascale
Tousseyn, Thomas
author_facet Vets, Johanna
Marcelis, Lukas
Schepers, Charlotte
Dorreman, Yaliva
Verbeek, Sanne
Vanwalleghem, Lieve
Gieraerts, Katrien
Meylaerts, Liesbeth
Lesaffer, Jan
Devos, Helena
Put, Natalie
Snauwaert, Sylvia
De Paepe, Pascale
Tousseyn, Thomas
author_sort Vets, Johanna
collection PubMed
description Breast-implant associated (BIA) lymphoma is an infrequent type of cancer occurring in the fluid and fibrous capsule around a textured breast implant. Recently, both the 2022 WHO 5th edition classification of Haematological tumours (WHO HAEM5) and 2022 International Consensus Classification of Mature Lymphoid Neoplasms (22ICC), recognized breast implant-associated Anaplastic Large Cell Lymphoma (BIA-ALCL) as a definitive entity, defined as a mature CD30-positive T-cell lymphoma, confined by a fibrous capsule, in a breast implant setting. Only few B-cell lymphomas have been reported in the literature to be associated with breast implants. Here we report two EBV-positive Diffuse Large B-cell lymphomas (EBV + DLBCL) in relation to a breast implant, both expressing CD30 as well as EBV latency type 3. Both lesions were considered as DLBCL associated with chronic inflammation (CI-DLBCL), but one presented as a 7 cm solid mass, while the other presented as a fibrin-associated DLBCL (FA-DLBCL) in an HIV patient. Clinically, both are in complete remission 6 months or longer after capsulectomy and graft removal, without additional chemotherapy. Such cases, characterized by large CD30-positive cells, can easily be misdiagnosed as BIA-ALCL if the cell of origin is not further established. Therefore, a diagnostic panel including lineage-specific B-and T-cell markers and EBER in situ hybridization is essential to recognize this rare entity, to understand lymphomagenesis, to predict outcome and to define clinical approach.
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spelling pubmed-101274232023-04-26 Breast implant associated EBV-positive Diffuse Large B-cell lymphoma: an underrecognized entity? Vets, Johanna Marcelis, Lukas Schepers, Charlotte Dorreman, Yaliva Verbeek, Sanne Vanwalleghem, Lieve Gieraerts, Katrien Meylaerts, Liesbeth Lesaffer, Jan Devos, Helena Put, Natalie Snauwaert, Sylvia De Paepe, Pascale Tousseyn, Thomas Diagn Pathol Case Report Breast-implant associated (BIA) lymphoma is an infrequent type of cancer occurring in the fluid and fibrous capsule around a textured breast implant. Recently, both the 2022 WHO 5th edition classification of Haematological tumours (WHO HAEM5) and 2022 International Consensus Classification of Mature Lymphoid Neoplasms (22ICC), recognized breast implant-associated Anaplastic Large Cell Lymphoma (BIA-ALCL) as a definitive entity, defined as a mature CD30-positive T-cell lymphoma, confined by a fibrous capsule, in a breast implant setting. Only few B-cell lymphomas have been reported in the literature to be associated with breast implants. Here we report two EBV-positive Diffuse Large B-cell lymphomas (EBV + DLBCL) in relation to a breast implant, both expressing CD30 as well as EBV latency type 3. Both lesions were considered as DLBCL associated with chronic inflammation (CI-DLBCL), but one presented as a 7 cm solid mass, while the other presented as a fibrin-associated DLBCL (FA-DLBCL) in an HIV patient. Clinically, both are in complete remission 6 months or longer after capsulectomy and graft removal, without additional chemotherapy. Such cases, characterized by large CD30-positive cells, can easily be misdiagnosed as BIA-ALCL if the cell of origin is not further established. Therefore, a diagnostic panel including lineage-specific B-and T-cell markers and EBER in situ hybridization is essential to recognize this rare entity, to understand lymphomagenesis, to predict outcome and to define clinical approach. BioMed Central 2023-04-25 /pmc/articles/PMC10127423/ /pubmed/37098615 http://dx.doi.org/10.1186/s13000-023-01337-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Vets, Johanna
Marcelis, Lukas
Schepers, Charlotte
Dorreman, Yaliva
Verbeek, Sanne
Vanwalleghem, Lieve
Gieraerts, Katrien
Meylaerts, Liesbeth
Lesaffer, Jan
Devos, Helena
Put, Natalie
Snauwaert, Sylvia
De Paepe, Pascale
Tousseyn, Thomas
Breast implant associated EBV-positive Diffuse Large B-cell lymphoma: an underrecognized entity?
title Breast implant associated EBV-positive Diffuse Large B-cell lymphoma: an underrecognized entity?
title_full Breast implant associated EBV-positive Diffuse Large B-cell lymphoma: an underrecognized entity?
title_fullStr Breast implant associated EBV-positive Diffuse Large B-cell lymphoma: an underrecognized entity?
title_full_unstemmed Breast implant associated EBV-positive Diffuse Large B-cell lymphoma: an underrecognized entity?
title_short Breast implant associated EBV-positive Diffuse Large B-cell lymphoma: an underrecognized entity?
title_sort breast implant associated ebv-positive diffuse large b-cell lymphoma: an underrecognized entity?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127423/
https://www.ncbi.nlm.nih.gov/pubmed/37098615
http://dx.doi.org/10.1186/s13000-023-01337-5
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