A Novel Tool to Identify Bactericidal Compounds against Vulnerable Targets in Drug-Tolerant M. tuberculosis found in Caseum

Caseous necrosis is a hallmark of tuberculosis (TB) pathology and creates a niche for drug-tolerant persisters within the host. Cavitary TB and high bacterial burden in caseum require longer treatment duration. An in vitro model that recapitulates the major features of Mycobacterium tuberculosis (Mt...

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Detalles Bibliográficos
Autores principales: Sarathy, Jansy P., Xie, Min, Jones, Richard M., Chang, Adrienne, Osiecki, Paulina, Weiner, Danielle, Tsao, Wen-Shan, Dougher, Maureen, Blanc, Landry, Fotouhi, Nader, Via, Laura E., Barry, Clifton E., De Vlaminck, Iwijn, Sherman, David R., Dartois, Véronique A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127596/
https://www.ncbi.nlm.nih.gov/pubmed/37017524
http://dx.doi.org/10.1128/mbio.00598-23

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