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Genetic Dissection of Budding Yeast PCNA Mutations Responsible for the Regulated Recruitment of Srs2 Helicase

DNA-damage tolerance (DDT) is a mechanism by which eukaryotes bypass replication-blocking lesions to resume DNA synthesis and maintain cell viability. In Saccharomyces cerevisiae, DDT is mediated by sequential ubiquitination and sumoylation of proliferating cell nuclear antigen (PCNA, encoded by POL...

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Detalles Bibliográficos
Autores principales: Fan, Li, Zhang, Wenqing, Rybchuk, Josephine, Luo, Yu, Xiao, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127746/
https://www.ncbi.nlm.nih.gov/pubmed/36861970
http://dx.doi.org/10.1128/mbio.00315-23