Neutralizing Anti-Granulocyte Macrophage-Colony Stimulating Factor Autoantibodies Recognize Post-Translational Glycosylations on Granulocyte Macrophage-Colony Stimulating Factor Years Before Diagnosis and Predict Complicated Crohn’s Disease

BACKGROUND & AIMS: Anti-granulocyte macrophage-colony stimulating factor autoantibodies (aGMAbs) are detected in patients with ileal Crohn’s disease (CD). Their induction and mode of action during or before disease are not well understood. We aimed to investigate the underlying mechanisms associ...

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Detalles Bibliográficos
Autores principales: Mortha, Arthur, Remark, Romain, Del Valle, Diane Marie, Chuang, Ling-Shiang, Chai, Zhi, Alves, Inês, Azevedo, Catarina, Gaifem, Joana, Martin, Jerome, Petralia, Francesca, Tuballes, Kevin, Barcessat, Vanessa, Tai, Siu Ling, Huang, Hsin-Hui, Laface, Ilaria, Jerez, Yeray Arteaga, Boschetti, Gilles, Villaverde, Nicole, Wang, Mona D., Korie, Ujunwa M., Murray, Joseph, Choung, Rok-Seon, Sato, Takahiro, Laird, Renee M., Plevy, Scott, Rahman, Adeeb, Torres, Joana, Porter, Chad, Riddle, Mark S., Kenigsberg, Ephraim, Pinho, Salomé S., Cho, Judy H., Merad, Miriam, Colombel, Jean-Frederic, Gnjatic, Sacha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127946/
https://www.ncbi.nlm.nih.gov/pubmed/35623454
http://dx.doi.org/10.1053/j.gastro.2022.05.029

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