Imprinting of Gut-Homing Receptors on Mtb-Specific Th1* Cells Is Associated with Reduced Lung Homing after Gavage BCG Vaccination of Rhesus Macaques

Alternative delivery routes of the current Mycobacterium tuberculosis (Mtb) vaccine, intradermally (ID) delivered BCG, may provide better protection against tuberculosis, and be more easily administered. Here, we use rhesus macaques to compare the airway immunogenicity of BCG delivered via either ID...

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Detalles Bibliográficos
Autores principales: Hoft, Stella G., Kauffman, Keith D., Sakai, Shunsuke, Lindestam Arlehamn, Cecilia S., Sette, Alessandro, Hoft, Daniel F., Herbert, Richard, Barber, Daniel L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10127997/
https://www.ncbi.nlm.nih.gov/pubmed/36880755
http://dx.doi.org/10.1128/mbio.00220-23

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