Cargando…

Activation of the Plasmodium Egress Effector Subtilisin-Like Protease 1 Is Mediated by Plasmepsin X Destruction of the Prodomain

Following each round of replication, daughter merozoites of the malaria parasite Plasmodium falciparum escape (egress) from the infected host red blood cell (RBC) by rupturing the parasitophorous vacuole membrane (PVM) and the RBC membrane (RBCM). A proteolytic cascade orchestrated by a parasite ser...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mukherjee, Sumit, Nasamu, Armiyaw S., Rubiano, Kelly C., Goldberg, Daniel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128010/ https://www.ncbi.nlm.nih.gov/pubmed/37036362 http://dx.doi.org/10.1128/mbio.00673-23

Ejemplares similares

Maturation and substrate processing topography of the Plasmodium falciparum invasion/egress protease plasmepsin X
por: Mukherjee, Sumit, et al.
Publicado: (2022)

Assessment of Biological Role and Insight into Druggability of the Plasmodium falciparum Protease Plasmepsin V
por: Polino, Alexander J., et al.
Publicado: (2020)

Plasmepsins IX and X are essential and druggable mediators of malaria parasite egress and invasion
por: Nasamu, Armiyaw S., et al.
Publicado: (2017)

The nepenthesin insert in the Plasmodium falciparum aspartic protease plasmepsin V is necessary for enzyme function
por: Polino, Alexander J., et al.
Publicado: (2022)

Plasmodium falciparum ookinete expression of plasmepsin VII and plasmepsin X
por: Li, Fengwu, et al.
Publicado: (2016)

Experimental Determination of the Membrane Topology of the Plasmodium Protease Plasmepsin V
por: Tarr, Sarah J., et al.
Publicado: (2015)

Egress and invasion machinery of malaria: an in-depth look into the structural and functional features of the flap dynamics of plasmepsin IX and X
por: Munsamy, Geraldene, et al.
Publicado: (2018)

Plasmepsin-like Aspartyl Proteases in Babesia
por: Šnebergerová, Pavla, et al.
Publicado: (2021)

The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin
por: Withers-Martinez, Chrislaine, et al.
Publicado: (2014)

Essentiality of Plasmodium falciparum plasmepsin V
por: Boonyalai, Nonlawat, et al.
Publicado: (2018)

Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte
por: Russo, Ilaria, et al.
Publicado: (2010)

Corrigendum: The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin
por: Withers-Martinez, Chrislaine, et al.
Publicado: (2014)

Trafficking of plasmepsin II to the food vacuole of the malaria parasite Plasmodium falciparum
por: Klemba, Michael, et al.
Publicado: (2004)

Regulatory Elements within the Prodomain of Falcipain-2, a Cysteine Protease of the Malaria Parasite Plasmodium falciparum
por: Pandey, Kailash C., et al.
Publicado: (2009)

A malaria parasite subtilisin propeptide-like protein is a potent inhibitor of the egress protease SUB1
por: Tarr, Sarah J., et al.
Publicado: (2020)

Molecular Determinants of Binding to the Plasmodium Subtilisin-like Protease 1
por: Fulle, Simone, et al.
Publicado: (2013)

EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX
por: Garten, Matthias, et al.
Publicado: (2018)

Inhibitory Potential of Prodomain of Plasmodium falciparum Protease Serine Repeat Antigen 5 for Asexual Blood Stages of Parasite
por: Alam, Asrar, et al.
Publicado: (2012)

Plasmodium falciparum Plasmepsin 2 Duplications, West Africa
por: Inoue, Juliana, et al.
Publicado: (2018)

Overexpression of plasmepsin II and plasmepsin III does not directly cause reduction in Plasmodium falciparum sensitivity to artesunate, chloroquine and piperaquine
por: Loesbanluechai, Duangkamon, et al.
Publicado: (2018)

Plasmepsin X activates the PCRCR complex of Plasmodium falciparum by processing PfRh5 for erythrocyte invasion
por: Triglia, Tony, et al.
Publicado: (2023)

A malarial cysteine protease is necessary for Plasmodium sporozoite egress from oocysts
por: Aly, Ahmed S.I., et al.
Publicado: (2005)

Computational Design of Protein-Based Inhibitors of Plasmodium vivax Subtilisin-Like 1 Protease
por: Bastianelli, Giacomo, et al.
Publicado: (2014)

Production of subtilisin proteases in bacteria and yeast
por: Rozanov, A.S., et al.
Publicado: (2021)

In Silico and In Vitro Antimalarial Screening and Validation Targeting Plasmodium falciparum Plasmepsin V
por: Ji, Xin, et al.
Publicado: (2022)

Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region
por: Gambini, Luca, et al.
Publicado: (2015)

The anti-Müllerian hormone prodomain is displaced from the hormone/prodomain complex upon bivalent binding to the hormone receptor
por: Cate, Richard L., et al.
Publicado: (2021)

Plasmepsin II–III copy number accounts for bimodal piperaquine resistance among Cambodian Plasmodium falciparum
por: Bopp, Selina, et al.
Publicado: (2018)

The mature N-termini of Plasmodium effector proteins confer specificity of export
por: Hasan, Muhammad M., et al.
Publicado: (2023)

Correction: Picomolar Inhibition of Plasmepsin V, an Essential Malaria Protease, Achieved Exploiting the Prime Region
por: Gambini, Luca, et al.
Publicado: (2016)

The Plasmodium berghei serine protease PbSUB1 plays an important role in male gamete egress
por: Pace, Tomasino, et al.
Publicado: (2019)

Bioprospection of Selected Plant Secondary Metabolites as Modulators of the Proteolytic Activity of Plasmodium falciparum Plasmepsin V
por: Sulyman, Abdulhakeem Olarewaju, et al.
Publicado: (2023)

An integrated platform for genome engineering and gene expression perturbation in Plasmodium falciparum
por: Nasamu, Armiyaw S., et al.
Publicado: (2021)

Substrate Peptidomimetic Inhibitors of P. falciparum Plasmepsin X with Potent Antimalarial Activity
por: Richardson, Lachlan W., et al.
Publicado: (2022)

Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity
por: Kovada, Vadims, et al.
Publicado: (2023)

Engineering subtilisin proteases that specifically degrade active RAS
por: Chen, Yingwei, et al.
Publicado: (2021)

Click Inspired Synthesis of Novel Cinchonidine Glycoconjugates as Promising Plasmepsin Inhibitors
por: Mishra, Nidhi, et al.
Publicado: (2020)

Malarial proteases and host cell egress: an ‘emerging’ cascade
por: Blackman, Michael J
Publicado: (2008)

Enzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium berghei
por: Liu, Peng, et al.
Publicado: (2015)

Understanding the structural basis of substrate recognition by Plasmodium falciparum plasmepsin V to aid in the design of potent inhibitors
por: Bedi, Rajiv K., et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_c4k2jitobivo4tpaaabk8is0bp