Fetal Loss in Pregnant Rabbits Infected with Genotype 3 Hepatitis E Virus Is Associated with Altered Inflammatory Responses, Enhanced Virus Replication, and Extrahepatic Virus Dissemination with Positive Correlations with Increased Estradiol Level

Hepatitis E virus (HEV) causes adverse clinical outcomes in pregnant women, but the underlying mechanisms remain poorly understood. To delineate the mechanisms of pregnancy-associated adverse effects during HEV infection, we utilized a genotype 3 HEV from rabbit (HEV-3ra) and its cognate host (rabbi...

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Detalles Bibliográficos
Autores principales: Mahsoub, Hassan M., Heffron, C. Lynn, Hassebroek, Anna M., Sooryanarain, Harini, Wang, Bo, LeRoith, Tanya, Rodríguez, Guillermo Raimundi, Tian, Debin, Meng, Xiang-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128027/
https://www.ncbi.nlm.nih.gov/pubmed/36939322
http://dx.doi.org/10.1128/mbio.00418-23

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