Amino acid polymorphisms in human histocompatibility leukocyte antigen class II and proinsulin epitope have impacts on type 1 diabetes mellitus induced by immune-checkpoint inhibitors

INTRODUCTION: Immune-checkpoint inhibitors are effective in various advanced cancers. Type 1 diabetes mellitus induced by them (ICI-T1DM) is a serious complication requiring prompt insulin treatment, but the immunological mechanism behind it is unclear. METHODS: We examined amino acid polymorphisms...

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Detalles Bibliográficos
Autores principales: Inaba, Hidefumi, Morita, Shuhei, Kosugi, Daisuke, Asai, Yuki, Kaido, Yosuke, Ito, Saya, Hirobata, Tomonao, Inoue, Gen, Yamamoto, Yuki, Jinnin, Masatoshi, Kimura, Hiroaki, Ota, Masao, Okudaira, Yuko, Nakatani, Hiroyasu, Kobayashi, Tomoko, Iwama, Shintaro, Arima, Hiroshi, Matsuoka, Takaaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128036/
https://www.ncbi.nlm.nih.gov/pubmed/37114039
http://dx.doi.org/10.3389/fimmu.2023.1165004

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