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Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile

Clostridioides difficile remains a key cause of healthcare-associated infection, with multidrug-resistant (MDR) lineages causing high-mortality (≥20%) outbreaks. Cephalosporin treatment is a long-established risk factor, and antimicrobial stewardship is a key control. A mechanism underlying raised c...

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Detalles Bibliográficos
Autores principales:	Dingle, Kate E., Freeman, Jane, Didelot, Xavier, Quan, T. Phuong, Eyre, David W., Swann, Jeremy, Spittal, William D., Clark, Emma V., Jolley, Keith A., Walker, A. Sarah, Wilcox, Mark H., Crook, Derrick W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128037/ https://www.ncbi.nlm.nih.gov/pubmed/37017518 http://dx.doi.org/10.1128/mbio.00243-23

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