Illuminating the Live-Cell Dynamics of Hepatitis B Virus Covalently Closed Circular DNA Using the CRISPR-Tag System

The covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) is the major obstacle to curing chronic hepatitis B (CHB). Current cccDNA detection methods are mostly based on biochemical extraction and bulk measurements. They nevertheless generated a general sketch of its biological features...

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Detalles Bibliográficos
Autores principales: Ding, Jiahui, Yi, Zhigang, Zai, Wenjing, Wu, Min, Chen, Baohui, Cai, Qiliang, Zhang, Xiaonan, Yuan, Zhenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128046/
https://www.ncbi.nlm.nih.gov/pubmed/36840581
http://dx.doi.org/10.1128/mbio.03550-22

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