Ribavirin Treatment Failure-Associated Mutation, Y1320H, in the RNA-Dependent RNA Polymerase of Genotype 3 Hepatitis E Virus (HEV) Enhances Virus Replication in a Rabbit HEV Infection Model

Chronic hepatitis E virus (HEV) infection has become a significant clinical problem that requires treatment in immunocompromised individuals. In the absence of an HEV-specific antiviral, ribavirin (RBV) has been used off-label, but treatment failure may occur due to mutations in the viral RNA-depend...

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Autores principales: Wang, Bo, Mahsoub, Hassan M., Li, Wen, Heffron, C. Lynn, Tian, Debin, Hassebroek, Anna M., LeRoith, Tanya, Meng, Xiang-Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128057/
https://www.ncbi.nlm.nih.gov/pubmed/36809085
http://dx.doi.org/10.1128/mbio.03372-22

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