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Acute Intermittent Porphyria Attack Triggered by COVID-19 Infection
A 45-year-old male patient who was diagnosed with acute intermittent porphyria (AIP) four years ago and had his last episode two years prior presented to our clinic with an AIP attack complicated with rhabdomyolysis triggered by coronavirus disease 2019 (COVID-19) infection. Although there are well-...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128887/ https://www.ncbi.nlm.nih.gov/pubmed/37113461 http://dx.doi.org/10.7759/cureus.37412 |
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author | Bardak, Ali Emre Alada, Mehmet Oğuzcan Senkal, Naci Alibeyoğlu, Alpay Köse, Murat |
author_facet | Bardak, Ali Emre Alada, Mehmet Oğuzcan Senkal, Naci Alibeyoğlu, Alpay Köse, Murat |
author_sort | Bardak, Ali Emre |
collection | PubMed |
description | A 45-year-old male patient who was diagnosed with acute intermittent porphyria (AIP) four years ago and had his last episode two years prior presented to our clinic with an AIP attack complicated with rhabdomyolysis triggered by coronavirus disease 2019 (COVID-19) infection. Although there are well-known factors that might trigger an AIP attack, some studies also showed an association of COVID-19 with porphyria. These studies suggest that the accumulation of by-products in the heme synthesis pathway during COVID-19 infection may cause attacks mimicking acute intermittent porphyria. In respect to that, in the early phases of the pandemic, hypotheses emerged arguing the treatment of severe COVID-19 infections with hemin as the treatment of an AIP attack. In our instance, after a two-year period during which there had not been an episode, there was no evident cause other than COVID-19 infection. We believe that patients with porphyria are particularly prone to exacerbations during a COVID-19 infection and should be monitored carefully. |
format | Online Article Text |
id | pubmed-10128887 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-101288872023-04-26 Acute Intermittent Porphyria Attack Triggered by COVID-19 Infection Bardak, Ali Emre Alada, Mehmet Oğuzcan Senkal, Naci Alibeyoğlu, Alpay Köse, Murat Cureus Internal Medicine A 45-year-old male patient who was diagnosed with acute intermittent porphyria (AIP) four years ago and had his last episode two years prior presented to our clinic with an AIP attack complicated with rhabdomyolysis triggered by coronavirus disease 2019 (COVID-19) infection. Although there are well-known factors that might trigger an AIP attack, some studies also showed an association of COVID-19 with porphyria. These studies suggest that the accumulation of by-products in the heme synthesis pathway during COVID-19 infection may cause attacks mimicking acute intermittent porphyria. In respect to that, in the early phases of the pandemic, hypotheses emerged arguing the treatment of severe COVID-19 infections with hemin as the treatment of an AIP attack. In our instance, after a two-year period during which there had not been an episode, there was no evident cause other than COVID-19 infection. We believe that patients with porphyria are particularly prone to exacerbations during a COVID-19 infection and should be monitored carefully. Cureus 2023-04-10 /pmc/articles/PMC10128887/ /pubmed/37113461 http://dx.doi.org/10.7759/cureus.37412 Text en Copyright © 2023, Bardak et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Bardak, Ali Emre Alada, Mehmet Oğuzcan Senkal, Naci Alibeyoğlu, Alpay Köse, Murat Acute Intermittent Porphyria Attack Triggered by COVID-19 Infection |
title | Acute Intermittent Porphyria Attack Triggered by COVID-19 Infection |
title_full | Acute Intermittent Porphyria Attack Triggered by COVID-19 Infection |
title_fullStr | Acute Intermittent Porphyria Attack Triggered by COVID-19 Infection |
title_full_unstemmed | Acute Intermittent Porphyria Attack Triggered by COVID-19 Infection |
title_short | Acute Intermittent Porphyria Attack Triggered by COVID-19 Infection |
title_sort | acute intermittent porphyria attack triggered by covid-19 infection |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128887/ https://www.ncbi.nlm.nih.gov/pubmed/37113461 http://dx.doi.org/10.7759/cureus.37412 |
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