High rifampicin peak plasma concentrations accelerate the slow phase of bacterial decline in tuberculosis patients: Evidence for heteroresistance

BACKGROUND: Antibiotic treatments are often associated with a late slowdown in bacterial killing. This separates the killing of bacteria into at least two distinct phases: a quick phase followed by a slower phase, the latter of which is linked to treatment success. Current mechanistic explanations f...

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Detalles Bibliográficos
Autores principales: Martinecz, Antal, Boeree, Martin J., Diacon, Andreas H., Dawson, Rodney, Hemez, Colin, Aarnoutse, Rob E., Abel zur Wiesch, Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128972/
https://www.ncbi.nlm.nih.gov/pubmed/37053266
http://dx.doi.org/10.1371/journal.pcbi.1011000

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10128972/
https://www.ncbi.nlm.nih.gov/pubmed/37053266
http://dx.doi.org/10.1371/journal.pcbi.1011000

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