A rad50 germline mutation induces tumorigenesis and ataxia-telangiectasia phenotype in a transparent medaka model

The MRE11A-RAD50-NBS1 complex activates the ataxia-telangiectasia mutated (ATM) pathway and plays a central role in genome homeostasis. The association of RAD50 mutations with disease remains unclear; hence, we adopted a medaka rad50 mutant to demonstrate the significance of RAD50 mutation in pathog...

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Detalles Bibliográficos
Autores principales: Chisada, Shinichi, Ohtsuka, Kouki, Fujiwara, Masachika, Yoshida, Masao, Matsushima, Satsuki, Watanabe, Takashi, Karita, Kanae, Ohnishi, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129005/
https://www.ncbi.nlm.nih.gov/pubmed/37098078
http://dx.doi.org/10.1371/journal.pone.0282277

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