Autophagy of the ER Requires Actin Assembly Driven by the Interaction of ER with Endocytic Pits

Autophagy of the cortical ER in budding yeast was unexpectedly found to require End3, a component of the endocytic machinery that promotes the assembly of actin at endocytic pits on the plasma membrane. The cortical ER transiently interacts with invaginating endocytic pits through a linkage consisti...

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Detalles Bibliográficos
Autores principales: Novick, Peter, Liu, Dongmei, Ferro-Novick, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
News and Views
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129067/
https://www.ncbi.nlm.nih.gov/pubmed/37102157
http://dx.doi.org/10.1177/25152564221093215
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author Novick, Peter
Liu, Dongmei
Ferro-Novick, Susan
author_facet Novick, Peter
Liu, Dongmei
Ferro-Novick, Susan
author_sort Novick, Peter
collection PubMed
description Autophagy of the cortical ER in budding yeast was unexpectedly found to require End3, a component of the endocytic machinery that promotes the assembly of actin at endocytic pits on the plasma membrane. The cortical ER transiently interacts with invaginating endocytic pits through a linkage consisting of VAP proteins, oxysterol binding proteins and type I myosins. These proteins are required for actin assembly and for autophagy of the ER. Assembly of actin at these contact sites may direct the movement of ER away from the cortex towards sites of autophagosome assembly.
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spelling pubmed-101290672023-04-25 Autophagy of the ER Requires Actin Assembly Driven by the Interaction of ER with Endocytic Pits Novick, Peter Liu, Dongmei Ferro-Novick, Susan Contact (Thousand Oaks) News and Views Autophagy of the cortical ER in budding yeast was unexpectedly found to require End3, a component of the endocytic machinery that promotes the assembly of actin at endocytic pits on the plasma membrane. The cortical ER transiently interacts with invaginating endocytic pits through a linkage consisting of VAP proteins, oxysterol binding proteins and type I myosins. These proteins are required for actin assembly and for autophagy of the ER. Assembly of actin at these contact sites may direct the movement of ER away from the cortex towards sites of autophagosome assembly. SAGE Publications 2022-04-13 /pmc/articles/PMC10129067/ /pubmed/37102157 http://dx.doi.org/10.1177/25152564221093215 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle News and Views
Novick, Peter
Liu, Dongmei
Ferro-Novick, Susan
Autophagy of the ER Requires Actin Assembly Driven by the Interaction of ER with Endocytic Pits
title Autophagy of the ER Requires Actin Assembly Driven by the Interaction of ER with Endocytic Pits
title_full Autophagy of the ER Requires Actin Assembly Driven by the Interaction of ER with Endocytic Pits
title_fullStr Autophagy of the ER Requires Actin Assembly Driven by the Interaction of ER with Endocytic Pits
title_full_unstemmed Autophagy of the ER Requires Actin Assembly Driven by the Interaction of ER with Endocytic Pits
title_short Autophagy of the ER Requires Actin Assembly Driven by the Interaction of ER with Endocytic Pits
title_sort autophagy of the er requires actin assembly driven by the interaction of er with endocytic pits
topic News and Views
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129067/
https://www.ncbi.nlm.nih.gov/pubmed/37102157
http://dx.doi.org/10.1177/25152564221093215
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