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Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report
Xanthogranulomatous cholecystitis (XGC) is an uncommon type of chronic cholecystitis. Clinical presentation, laboratory findings, and radiological analysis mimic gallbladder carcinoma. A definitive diagnosis is made by histological study. Cholecystectomy, along with adjuncts as required, is performe...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129170/ https://www.ncbi.nlm.nih.gov/pubmed/37113911 http://dx.doi.org/10.1097/MS9.0000000000000363 |
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author | Rijal, Sabina Basukala, Sunil Shah, Kunda B. Thapa, Anup Bohara, Sujan Shah, Aashish |
author_facet | Rijal, Sabina Basukala, Sunil Shah, Kunda B. Thapa, Anup Bohara, Sujan Shah, Aashish |
author_sort | Rijal, Sabina |
collection | PubMed |
description | Xanthogranulomatous cholecystitis (XGC) is an uncommon type of chronic cholecystitis. Clinical presentation, laboratory findings, and radiological analysis mimic gallbladder carcinoma. A definitive diagnosis is made by histological study. Cholecystectomy, along with adjuncts as required, is performed for management. CASE PRESENTATION: We present a case of a 67-year-old female who was planned for interval cholecystectomy for gallstone pancreatitis. Her clinical, laboratory and radiological findings were suggestive of cholelithiasis and was planned for laparoscopic cholecystectomy. Her intraoperative findings mimicked gallbladder carcinoma. The surgery was aborted, and a biopsy was sent for histopathological analysis. XGC was diagnosed, and the patient underwent laparoscopic cholecystectomy with no postoperative complications during the 6-month follow-up period. DISCUSSION: XGC is a rare disorder resulting from chronic inflammation of the gallbladder. There is the presence of xanthogranuloma with predominant lipid-laden macrophages in the gallbladder wall along with fibrosis. Clinical presentation, laboratory findings, and radiological analysis mimic gallbladder carcinoma. Ultrasonography usually shows diffuse wall thickening of the gallbladder, intramural hypoechoic nodules, unclear liver and gallbladder interface, and the presence of gallstones. The final diagnosis is made by histopathological analysis. Laparoscopic or open cholecystectomy, along with adjuncts as required, is performed for management with a low postoperative complication rate. CONCLUSION: XGC is a rare, benign disease that is often confused with gallbladder cancer before histological analysis. XGC can be managed with laparoscopic cholecystectomy with minimal postoperative complications. |
format | Online Article Text |
id | pubmed-10129170 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-101291702023-04-26 Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report Rijal, Sabina Basukala, Sunil Shah, Kunda B. Thapa, Anup Bohara, Sujan Shah, Aashish Ann Med Surg (Lond) Case Reports Xanthogranulomatous cholecystitis (XGC) is an uncommon type of chronic cholecystitis. Clinical presentation, laboratory findings, and radiological analysis mimic gallbladder carcinoma. A definitive diagnosis is made by histological study. Cholecystectomy, along with adjuncts as required, is performed for management. CASE PRESENTATION: We present a case of a 67-year-old female who was planned for interval cholecystectomy for gallstone pancreatitis. Her clinical, laboratory and radiological findings were suggestive of cholelithiasis and was planned for laparoscopic cholecystectomy. Her intraoperative findings mimicked gallbladder carcinoma. The surgery was aborted, and a biopsy was sent for histopathological analysis. XGC was diagnosed, and the patient underwent laparoscopic cholecystectomy with no postoperative complications during the 6-month follow-up period. DISCUSSION: XGC is a rare disorder resulting from chronic inflammation of the gallbladder. There is the presence of xanthogranuloma with predominant lipid-laden macrophages in the gallbladder wall along with fibrosis. Clinical presentation, laboratory findings, and radiological analysis mimic gallbladder carcinoma. Ultrasonography usually shows diffuse wall thickening of the gallbladder, intramural hypoechoic nodules, unclear liver and gallbladder interface, and the presence of gallstones. The final diagnosis is made by histopathological analysis. Laparoscopic or open cholecystectomy, along with adjuncts as required, is performed for management with a low postoperative complication rate. CONCLUSION: XGC is a rare, benign disease that is often confused with gallbladder cancer before histological analysis. XGC can be managed with laparoscopic cholecystectomy with minimal postoperative complications. Lippincott Williams & Wilkins 2023-03-27 /pmc/articles/PMC10129170/ /pubmed/37113911 http://dx.doi.org/10.1097/MS9.0000000000000363 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (https://creativecommons.org/licenses/by-nc/4.0/) (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) |
spellingShingle | Case Reports Rijal, Sabina Basukala, Sunil Shah, Kunda B. Thapa, Anup Bohara, Sujan Shah, Aashish Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report |
title | Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report |
title_full | Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report |
title_fullStr | Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report |
title_full_unstemmed | Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report |
title_short | Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report |
title_sort | xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report |
topic | Case Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129170/ https://www.ncbi.nlm.nih.gov/pubmed/37113911 http://dx.doi.org/10.1097/MS9.0000000000000363 |
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