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Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report

Xanthogranulomatous cholecystitis (XGC) is an uncommon type of chronic cholecystitis. Clinical presentation, laboratory findings, and radiological analysis mimic gallbladder carcinoma. A definitive diagnosis is made by histological study. Cholecystectomy, along with adjuncts as required, is performe...

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Autores principales: Rijal, Sabina, Basukala, Sunil, Shah, Kunda B., Thapa, Anup, Bohara, Sujan, Shah, Aashish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129170/
https://www.ncbi.nlm.nih.gov/pubmed/37113911
http://dx.doi.org/10.1097/MS9.0000000000000363
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author Rijal, Sabina
Basukala, Sunil
Shah, Kunda B.
Thapa, Anup
Bohara, Sujan
Shah, Aashish
author_facet Rijal, Sabina
Basukala, Sunil
Shah, Kunda B.
Thapa, Anup
Bohara, Sujan
Shah, Aashish
author_sort Rijal, Sabina
collection PubMed
description Xanthogranulomatous cholecystitis (XGC) is an uncommon type of chronic cholecystitis. Clinical presentation, laboratory findings, and radiological analysis mimic gallbladder carcinoma. A definitive diagnosis is made by histological study. Cholecystectomy, along with adjuncts as required, is performed for management. CASE PRESENTATION: We present a case of a 67-year-old female who was planned for interval cholecystectomy for gallstone pancreatitis. Her clinical, laboratory and radiological findings were suggestive of cholelithiasis and was planned for laparoscopic cholecystectomy. Her intraoperative findings mimicked gallbladder carcinoma. The surgery was aborted, and a biopsy was sent for histopathological analysis. XGC was diagnosed, and the patient underwent laparoscopic cholecystectomy with no postoperative complications during the 6-month follow-up period. DISCUSSION: XGC is a rare disorder resulting from chronic inflammation of the gallbladder. There is the presence of xanthogranuloma with predominant lipid-laden macrophages in the gallbladder wall along with fibrosis. Clinical presentation, laboratory findings, and radiological analysis mimic gallbladder carcinoma. Ultrasonography usually shows diffuse wall thickening of the gallbladder, intramural hypoechoic nodules, unclear liver and gallbladder interface, and the presence of gallstones. The final diagnosis is made by histopathological analysis. Laparoscopic or open cholecystectomy, along with adjuncts as required, is performed for management with a low postoperative complication rate. CONCLUSION: XGC is a rare, benign disease that is often confused with gallbladder cancer before histological analysis. XGC can be managed with laparoscopic cholecystectomy with minimal postoperative complications.
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spelling pubmed-101291702023-04-26 Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report Rijal, Sabina Basukala, Sunil Shah, Kunda B. Thapa, Anup Bohara, Sujan Shah, Aashish Ann Med Surg (Lond) Case Reports Xanthogranulomatous cholecystitis (XGC) is an uncommon type of chronic cholecystitis. Clinical presentation, laboratory findings, and radiological analysis mimic gallbladder carcinoma. A definitive diagnosis is made by histological study. Cholecystectomy, along with adjuncts as required, is performed for management. CASE PRESENTATION: We present a case of a 67-year-old female who was planned for interval cholecystectomy for gallstone pancreatitis. Her clinical, laboratory and radiological findings were suggestive of cholelithiasis and was planned for laparoscopic cholecystectomy. Her intraoperative findings mimicked gallbladder carcinoma. The surgery was aborted, and a biopsy was sent for histopathological analysis. XGC was diagnosed, and the patient underwent laparoscopic cholecystectomy with no postoperative complications during the 6-month follow-up period. DISCUSSION: XGC is a rare disorder resulting from chronic inflammation of the gallbladder. There is the presence of xanthogranuloma with predominant lipid-laden macrophages in the gallbladder wall along with fibrosis. Clinical presentation, laboratory findings, and radiological analysis mimic gallbladder carcinoma. Ultrasonography usually shows diffuse wall thickening of the gallbladder, intramural hypoechoic nodules, unclear liver and gallbladder interface, and the presence of gallstones. The final diagnosis is made by histopathological analysis. Laparoscopic or open cholecystectomy, along with adjuncts as required, is performed for management with a low postoperative complication rate. CONCLUSION: XGC is a rare, benign disease that is often confused with gallbladder cancer before histological analysis. XGC can be managed with laparoscopic cholecystectomy with minimal postoperative complications. Lippincott Williams & Wilkins 2023-03-27 /pmc/articles/PMC10129170/ /pubmed/37113911 http://dx.doi.org/10.1097/MS9.0000000000000363 Text en Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (https://creativecommons.org/licenses/by-nc/4.0/) (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/)
spellingShingle Case Reports
Rijal, Sabina
Basukala, Sunil
Shah, Kunda B.
Thapa, Anup
Bohara, Sujan
Shah, Aashish
Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report
title Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report
title_full Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report
title_fullStr Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report
title_full_unstemmed Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report
title_short Xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report
title_sort xanthogranulomatous cholecystitis mimicking gallbladder carcinoma: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129170/
https://www.ncbi.nlm.nih.gov/pubmed/37113911
http://dx.doi.org/10.1097/MS9.0000000000000363
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