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Fast, accurate antibody structure prediction from deep learning on massive set of natural antibodies

Antibodies have the capacity to bind a diverse set of antigens, and they have become critical therapeutics and diagnostic molecules. The binding of antibodies is facilitated by a set of six hypervariable loops that are diversified through genetic recombination and mutation. Even with recent advances...

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Detalles Bibliográficos
Autores principales: Ruffolo, Jeffrey A., Chu, Lee-Shin, Mahajan, Sai Pooja, Gray, Jeffrey J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129313/
https://www.ncbi.nlm.nih.gov/pubmed/37185622
http://dx.doi.org/10.1038/s41467-023-38063-x