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Pattern and predictors of cervical epithelial cell abnormalities among unscreened and under-screened women in Lagos, Nigeria: a cross-sectional study

Women who had never undergone cervical screening (CS) or who have infrequent CS are at increased risk of having cervical epithelial cell abnormalities (CECA) that may lead to cervical cancer (CCa). Our study determined the pattern and factors that predict the occurrence of CECA among unscreened and...

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Autores principales: Okunowo, Adeyemi Adebola, Ugwu, Aloy Okechukwu, Ajose, Azeezat Oluwafunmilayo, Kuku, Jubril Oladapo, Okunowo, Bolanle Olajumoke, Ani-Ugwu, Nneoma Kwemtochukwu, Osunwusi, Benedetto Oluwaseun, Adenekan, Muisi Alli, Soibi-Harry, Adaiah Priscillia, Garba, Sunusi Rimi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cancer Intelligence 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129382/
https://www.ncbi.nlm.nih.gov/pubmed/37113726
http://dx.doi.org/10.3332/ecancer.2023.1504
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author Okunowo, Adeyemi Adebola
Ugwu, Aloy Okechukwu
Ajose, Azeezat Oluwafunmilayo
Kuku, Jubril Oladapo
Okunowo, Bolanle Olajumoke
Ani-Ugwu, Nneoma Kwemtochukwu
Osunwusi, Benedetto Oluwaseun
Adenekan, Muisi Alli
Soibi-Harry, Adaiah Priscillia
Garba, Sunusi Rimi
author_facet Okunowo, Adeyemi Adebola
Ugwu, Aloy Okechukwu
Ajose, Azeezat Oluwafunmilayo
Kuku, Jubril Oladapo
Okunowo, Bolanle Olajumoke
Ani-Ugwu, Nneoma Kwemtochukwu
Osunwusi, Benedetto Oluwaseun
Adenekan, Muisi Alli
Soibi-Harry, Adaiah Priscillia
Garba, Sunusi Rimi
author_sort Okunowo, Adeyemi Adebola
collection PubMed
description Women who had never undergone cervical screening (CS) or who have infrequent CS are at increased risk of having cervical epithelial cell abnormalities (CECA) that may lead to cervical cancer (CCa). Our study determined the pattern and factors that predict the occurrence of CECA among unscreened and under-screened women in Lagos, Nigeria. This was an analytical cross-sectional study among 256 consenting sexually active women between 21 and 65 years who attended a community CS programme in Surulere, Lagos, Nigeria, in June 2019. Information on socio-demographic, reproductive, sexual, behavioural and clinical characteristics were collected and a Pap smear test was done. Women with abnormal cervical cytology were followed up and given appropriate treatment. Data analysis was done using Statistical Package for Social Sciences version 23. Descriptive statistics were computed using frequencies and association was tested using odd ratio. The participants’ mean age was 42.7 ± 10.3 years, majority were married (79.9%) and were human immune deficiency syndrome (HIV) negative (63.1%). The prevalence of CECA was 9.8%. Atypical squamous cell of undetermined significance and atypical squamous cell cannot exclude high-grade squamous intraepithelial lesion were the most common CECA with prevalence rates of 7.4% and 2.0%, respectively. Having a partner with multiple sexual partners (adjusted odd ratio (AOR) = 19.23), being HIV positive (AOR = 25.61), giving birth for the first time before the age of 26 years (AOR = 5.55) and presence of a combination of either abnormal vaginal discharge, contact bleeding or an unhealthy cervix on clinical examination (AOR = 13.65) independently predicted the occurrence of CECA. There is a need to prioritise CS for women with these risk factors to prevent CCa and reduce the burden of the disease in our environment.
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spelling pubmed-101293822023-04-26 Pattern and predictors of cervical epithelial cell abnormalities among unscreened and under-screened women in Lagos, Nigeria: a cross-sectional study Okunowo, Adeyemi Adebola Ugwu, Aloy Okechukwu Ajose, Azeezat Oluwafunmilayo Kuku, Jubril Oladapo Okunowo, Bolanle Olajumoke Ani-Ugwu, Nneoma Kwemtochukwu Osunwusi, Benedetto Oluwaseun Adenekan, Muisi Alli Soibi-Harry, Adaiah Priscillia Garba, Sunusi Rimi Ecancermedicalscience Research Women who had never undergone cervical screening (CS) or who have infrequent CS are at increased risk of having cervical epithelial cell abnormalities (CECA) that may lead to cervical cancer (CCa). Our study determined the pattern and factors that predict the occurrence of CECA among unscreened and under-screened women in Lagos, Nigeria. This was an analytical cross-sectional study among 256 consenting sexually active women between 21 and 65 years who attended a community CS programme in Surulere, Lagos, Nigeria, in June 2019. Information on socio-demographic, reproductive, sexual, behavioural and clinical characteristics were collected and a Pap smear test was done. Women with abnormal cervical cytology were followed up and given appropriate treatment. Data analysis was done using Statistical Package for Social Sciences version 23. Descriptive statistics were computed using frequencies and association was tested using odd ratio. The participants’ mean age was 42.7 ± 10.3 years, majority were married (79.9%) and were human immune deficiency syndrome (HIV) negative (63.1%). The prevalence of CECA was 9.8%. Atypical squamous cell of undetermined significance and atypical squamous cell cannot exclude high-grade squamous intraepithelial lesion were the most common CECA with prevalence rates of 7.4% and 2.0%, respectively. Having a partner with multiple sexual partners (adjusted odd ratio (AOR) = 19.23), being HIV positive (AOR = 25.61), giving birth for the first time before the age of 26 years (AOR = 5.55) and presence of a combination of either abnormal vaginal discharge, contact bleeding or an unhealthy cervix on clinical examination (AOR = 13.65) independently predicted the occurrence of CECA. There is a need to prioritise CS for women with these risk factors to prevent CCa and reduce the burden of the disease in our environment. Cancer Intelligence 2023-02-06 /pmc/articles/PMC10129382/ /pubmed/37113726 http://dx.doi.org/10.3332/ecancer.2023.1504 Text en © the authors; licensee ecancermedicalscience. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Okunowo, Adeyemi Adebola
Ugwu, Aloy Okechukwu
Ajose, Azeezat Oluwafunmilayo
Kuku, Jubril Oladapo
Okunowo, Bolanle Olajumoke
Ani-Ugwu, Nneoma Kwemtochukwu
Osunwusi, Benedetto Oluwaseun
Adenekan, Muisi Alli
Soibi-Harry, Adaiah Priscillia
Garba, Sunusi Rimi
Pattern and predictors of cervical epithelial cell abnormalities among unscreened and under-screened women in Lagos, Nigeria: a cross-sectional study
title Pattern and predictors of cervical epithelial cell abnormalities among unscreened and under-screened women in Lagos, Nigeria: a cross-sectional study
title_full Pattern and predictors of cervical epithelial cell abnormalities among unscreened and under-screened women in Lagos, Nigeria: a cross-sectional study
title_fullStr Pattern and predictors of cervical epithelial cell abnormalities among unscreened and under-screened women in Lagos, Nigeria: a cross-sectional study
title_full_unstemmed Pattern and predictors of cervical epithelial cell abnormalities among unscreened and under-screened women in Lagos, Nigeria: a cross-sectional study
title_short Pattern and predictors of cervical epithelial cell abnormalities among unscreened and under-screened women in Lagos, Nigeria: a cross-sectional study
title_sort pattern and predictors of cervical epithelial cell abnormalities among unscreened and under-screened women in lagos, nigeria: a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129382/
https://www.ncbi.nlm.nih.gov/pubmed/37113726
http://dx.doi.org/10.3332/ecancer.2023.1504
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