371 Fractalkine isoforms using gene therapy differentially regulate microglia activation and vascular damage in the diabetic retina

OBJECTIVES/GOALS: Retinal inflammation caused by the activation of resident macrophages (microglia) during diabetes exacerbates glial cell dysfunction, resulting in neuronal loss. The goal is to use rAAV gene therapy to deliver neuronal-derived fractalkine (FKN), minimizing inflammation and vascular...

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Detalles Bibliográficos
Autores principales: Rodriguez, Derek, Church, Kaira A., Pietramale, Alicia N., Cardona, Sandra M., Vanegas, Difernando, Muzzio, Isabel A., Nash, Kevin R., Cardona, Astrid E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Precision Medicine/Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129559/
http://dx.doi.org/10.1017/cts.2023.409

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