294 Identification of MCAK Inhibitors that Induce Aneuploidy in Triple Negative Breast Cancer Models

OBJECTIVES/GOALS: Microtubule poisons, like Taxol, are used to treat triple negative breast cancer (TNBC) and may induce lethal aneuploidy in cancer cells. Patients initially respond, but often develop drug resistance. New targeted drugs that cause aneuploidy may be a valuable approach to therapy. O...

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Detalles Bibliográficos
Autores principales: Smith, John, Husted, Stefan, Pilrose, Jay, Kuchangi, Disha, Ems-McClung, Stephanie C., Carpenter, Richard L., Walczak, Claire E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2023
Materias:
Precision Medicine/Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129656/
http://dx.doi.org/10.1017/cts.2023.349

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129656/
http://dx.doi.org/10.1017/cts.2023.349

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