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298 Identifying vaginal microbiome profiles that influence tenofovir distribution in the female genital tract

OBJECTIVES/GOALS: An ex-vivo tissue model has been developed to predict target concentrations of tenofovir diphosphate (TFVdp; active metabolite of tenofovir) but has not been utilized to see how vaginal dysbiosis affects TFVdp/dATP exposure in female genital tract (FGT). My central hypothesis is th...

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Detalles Bibliográficos
Autores principales:	Lantz, Alyssa M., Staley, Christopher, Nicol, Melanie R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cambridge University Press 2023
Materias:	Precision Medicine/Health
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129730/ http://dx.doi.org/10.1017/cts.2023.353

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