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Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma—a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation

BACKGROUND: Liver resection and local ablation are the only curative treatment for non-cirrhotic hepatocellular carcinoma (HCC). Few data exist concerning the prognosis of patients resected for non-cirrhotic HCC. The objectives of this study were to determine the prognostic factors of recurrence-fre...

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Autores principales: Maulat, Charlotte, Truant, Stéphanie, Hobeika, Christian, Barbier, Louise, Herrero, Astrid, Doussot, Alexandre, Gagnière, Johan, Girard, Édouard, Tranchart, Hadrien, Regimbeau, Jean-Marc, Fuks, David, Cauchy, François, Prodeau, Mathieu, Notte, Antoine, Toubert, Cyprien, Salamé, Ephrem, El Amrani, Mehdi, Andrieu, Sandrine, Muscari, Fabrice, Shourick, Jason, Suc, Bertrand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129883/
https://www.ncbi.nlm.nih.gov/pubmed/37124677
http://dx.doi.org/10.21037/hbsn-22-33
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author Maulat, Charlotte
Truant, Stéphanie
Hobeika, Christian
Barbier, Louise
Herrero, Astrid
Doussot, Alexandre
Gagnière, Johan
Girard, Édouard
Tranchart, Hadrien
Regimbeau, Jean-Marc
Fuks, David
Cauchy, François
Prodeau, Mathieu
Notte, Antoine
Toubert, Cyprien
Salamé, Ephrem
El Amrani, Mehdi
Andrieu, Sandrine
Muscari, Fabrice
Shourick, Jason
Suc, Bertrand
author_facet Maulat, Charlotte
Truant, Stéphanie
Hobeika, Christian
Barbier, Louise
Herrero, Astrid
Doussot, Alexandre
Gagnière, Johan
Girard, Édouard
Tranchart, Hadrien
Regimbeau, Jean-Marc
Fuks, David
Cauchy, François
Prodeau, Mathieu
Notte, Antoine
Toubert, Cyprien
Salamé, Ephrem
El Amrani, Mehdi
Andrieu, Sandrine
Muscari, Fabrice
Shourick, Jason
Suc, Bertrand
author_sort Maulat, Charlotte
collection PubMed
description BACKGROUND: Liver resection and local ablation are the only curative treatment for non-cirrhotic hepatocellular carcinoma (HCC). Few data exist concerning the prognosis of patients resected for non-cirrhotic HCC. The objectives of this study were to determine the prognostic factors of recurrence-free survival (RFS) and overall survival (OS) and to develop a prognostication algorithm for non-cirrhotic HCC. METHODS: French multicenter retrospective study including HCC patients with non-cirrhotic liver without underlying viral hepatitis: F0, F1 or F2 fibrosis. RESULTS: A total of 467 patients were included in 11 centers from 2010 to 2018. Non-cirrhotic liver had a fibrosis score of F0 (n=237, 50.7%), F1 (n=127, 27.2%) or F2 (n=103, 22.1%). OS and RFS at 5 years were 59.2% and 34.5%, respectively. In multivariate analysis, microvascular invasion and HCC differentiation were prognostic factors of OS and RFS and the number and size were prognostic factors of RFS (P<0.005). Stratification based on RFS provided an algorithm based on size (P=0.013) and number (P<0.001): 2 HCC with the largest nodule ≤10 cm (n=271, Group 1); 2 HCC with a nodule >10 cm (n=176, Group 2); >2 HCC regardless of size (n=20, Group 3). The 5-year RFS rates were 52.7% (Group 1), 30.1% (Group 2) and 5% (Group 3). CONCLUSIONS: We developed a prognostication algorithm based on the number (≤ or >2) and size (≤ or >10 cm), which could be used as a treatment decision support concerning the need for perioperative therapy. In case of bifocal HCC, surgery should not be a contraindication.
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spelling pubmed-101298832023-04-27 Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma—a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation Maulat, Charlotte Truant, Stéphanie Hobeika, Christian Barbier, Louise Herrero, Astrid Doussot, Alexandre Gagnière, Johan Girard, Édouard Tranchart, Hadrien Regimbeau, Jean-Marc Fuks, David Cauchy, François Prodeau, Mathieu Notte, Antoine Toubert, Cyprien Salamé, Ephrem El Amrani, Mehdi Andrieu, Sandrine Muscari, Fabrice Shourick, Jason Suc, Bertrand Hepatobiliary Surg Nutr Original Article BACKGROUND: Liver resection and local ablation are the only curative treatment for non-cirrhotic hepatocellular carcinoma (HCC). Few data exist concerning the prognosis of patients resected for non-cirrhotic HCC. The objectives of this study were to determine the prognostic factors of recurrence-free survival (RFS) and overall survival (OS) and to develop a prognostication algorithm for non-cirrhotic HCC. METHODS: French multicenter retrospective study including HCC patients with non-cirrhotic liver without underlying viral hepatitis: F0, F1 or F2 fibrosis. RESULTS: A total of 467 patients were included in 11 centers from 2010 to 2018. Non-cirrhotic liver had a fibrosis score of F0 (n=237, 50.7%), F1 (n=127, 27.2%) or F2 (n=103, 22.1%). OS and RFS at 5 years were 59.2% and 34.5%, respectively. In multivariate analysis, microvascular invasion and HCC differentiation were prognostic factors of OS and RFS and the number and size were prognostic factors of RFS (P<0.005). Stratification based on RFS provided an algorithm based on size (P=0.013) and number (P<0.001): 2 HCC with the largest nodule ≤10 cm (n=271, Group 1); 2 HCC with a nodule >10 cm (n=176, Group 2); >2 HCC regardless of size (n=20, Group 3). The 5-year RFS rates were 52.7% (Group 1), 30.1% (Group 2) and 5% (Group 3). CONCLUSIONS: We developed a prognostication algorithm based on the number (≤ or >2) and size (≤ or >10 cm), which could be used as a treatment decision support concerning the need for perioperative therapy. In case of bifocal HCC, surgery should not be a contraindication. AME Publishing Company 2022-09-22 2023-04-10 /pmc/articles/PMC10129883/ /pubmed/37124677 http://dx.doi.org/10.21037/hbsn-22-33 Text en 2023 Hepatobiliary Surgery and Nutrition. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Original Article
Maulat, Charlotte
Truant, Stéphanie
Hobeika, Christian
Barbier, Louise
Herrero, Astrid
Doussot, Alexandre
Gagnière, Johan
Girard, Édouard
Tranchart, Hadrien
Regimbeau, Jean-Marc
Fuks, David
Cauchy, François
Prodeau, Mathieu
Notte, Antoine
Toubert, Cyprien
Salamé, Ephrem
El Amrani, Mehdi
Andrieu, Sandrine
Muscari, Fabrice
Shourick, Jason
Suc, Bertrand
Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma—a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation
title Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma—a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation
title_full Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma—a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation
title_fullStr Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma—a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation
title_full_unstemmed Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma—a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation
title_short Prognostication algorithm for non-cirrhotic non-B non-C hepatocellular carcinoma—a multicenter study under the aegis of the French Association of Hepato-Biliary Surgery and liver Transplantation
title_sort prognostication algorithm for non-cirrhotic non-b non-c hepatocellular carcinoma—a multicenter study under the aegis of the french association of hepato-biliary surgery and liver transplantation
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10129883/
https://www.ncbi.nlm.nih.gov/pubmed/37124677
http://dx.doi.org/10.21037/hbsn-22-33
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