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miR-483-5p offsets functional and behavioural effects of stress in male mice through synapse-targeted repression of Pgap2 in the basolateral amygdala
Severe psychological trauma triggers genetic, biochemical and morphological changes in amygdala neurons, which underpin the development of stress-induced behavioural abnormalities, such as high levels of anxiety. miRNAs are small, non-coding RNA fragments that orchestrate complex neuronal responses...
Autores principales: | Mucha, Mariusz, Skrzypiec, Anna E., Kolenchery, Jaison B., Brambilla, Valentina, Patel, Satyam, Labrador-Ramos, Alberto, Kudla, Lucja, Murrall, Kathryn, Skene, Nathan, Dymicka-Piekarska, Violetta, Klejman, Agata, Przewlocki, Ryszard, Mosienko, Valentina, Pawlak, Robert |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130081/ https://www.ncbi.nlm.nih.gov/pubmed/37185241 http://dx.doi.org/10.1038/s41467-023-37688-2 |
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