TC-G 1008 facilitates epileptogenesis by acting selectively at the GPR39 receptor but non-selectively activates CREB in the hippocampus of pentylenetetrazole-kindled mice

The pharmacological activation of the GPR39 receptor has been proposed as a novel strategy for treating seizures; however, this hypothesis has not been verified experimentally. TC-G 1008 is a small molecule agonist increasingly used to study GPR39 receptor function but has not been validated using g...

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Detalles Bibliográficos
Autores principales: Doboszewska, Urszula, Socała, Katarzyna, Pieróg, Mateusz, Nieoczym, Dorota, Sawicki, Jan, Szafarz, Małgorzata, Gawel, Kinga, Rafało-Ulińska, Anna, Sajnóg, Adam, Wyska, Elżbieta, Esguerra, Camila V., Szewczyk, Bernadeta, Maćkowiak, Marzena, Barałkiewicz, Danuta, Mlyniec, Katarzyna, Nowak, Gabriel, Sowa, Ireneusz, Wlaź, Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130118/
https://www.ncbi.nlm.nih.gov/pubmed/37185787
http://dx.doi.org/10.1007/s00018-023-04766-z

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