Human CD4 cytotoxic T lymphocytes mediate potent tumor control in humanized immune system mice

Efficacy of immune checkpoint inhibitors in cancers can be limited by CD8 T cell dysfunction or HLA-I down-regulation. Tumor control mechanisms independent of CD8/HLA-I axis would overcome these limitations. Here, we report potent CD4 T cell-mediated tumor regression and memory responses in humanize...

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Detalles Bibliográficos
Autores principales: Lin, Wen, Singh, Varan, Springer, Raynel, Choonoo, Gabrielle, Gupta, Namita, Patel, Aditi, Frleta, Davor, Zhong, Jun, Owczarek, Tomasz, Decker, Corinne, Macdonald, Lynn, Murphy, Andrew, Thurston, Gavin, Mohrs, Markus, Ioffe, Ella, Lu, Yi-Fen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130128/
https://www.ncbi.nlm.nih.gov/pubmed/37185301
http://dx.doi.org/10.1038/s42003-023-04812-3

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