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Role of pyroptosis in the pathogenesis and treatment of diseases
Programmed cell death (PCD) is regarded as a pathological form of cell death with an intracellular program mediated, which plays a pivotal role in maintaining homeostasis and embryonic development. Pyroptosis is a new paradigm of PCD, which has received increasing attention due to its close associat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130418/ https://www.ncbi.nlm.nih.gov/pubmed/37125240 http://dx.doi.org/10.1002/mco2.249 |
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author | Jin, Xiangyu Ma, Yinchu Liu, Didi Huang, Yi |
author_facet | Jin, Xiangyu Ma, Yinchu Liu, Didi Huang, Yi |
author_sort | Jin, Xiangyu |
collection | PubMed |
description | Programmed cell death (PCD) is regarded as a pathological form of cell death with an intracellular program mediated, which plays a pivotal role in maintaining homeostasis and embryonic development. Pyroptosis is a new paradigm of PCD, which has received increasing attention due to its close association with immunity and disease. Pyroptosis is a form of inflammatory cell death mediated by gasdermin that promotes the release of proinflammatory cytokines and contents induced by inflammasome activation. Recently, increasing evidence in studies shows that pyroptosis has a crucial role in inflammatory conditions like cardiovascular diseases (CVDs), cancer, neurological diseases (NDs), and metabolic diseases (MDs), suggesting that targeting cell death is a potential intervention for the treatment of these inflammatory diseases. Based on this, the review aims to identify the molecular mechanisms and signaling pathways related to pyroptosis activation and summarizes the current insights into the complicated relationship between pyroptosis and multiple human inflammatory diseases (CVDs, cancer, NDs, and MDs). We also discuss a promising novel strategy and method for treating these inflammatory diseases by targeting pyroptosis and focus on the pyroptosis pathway application in clinics. |
format | Online Article Text |
id | pubmed-10130418 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101304182023-04-27 Role of pyroptosis in the pathogenesis and treatment of diseases Jin, Xiangyu Ma, Yinchu Liu, Didi Huang, Yi MedComm (2020) Reviews Programmed cell death (PCD) is regarded as a pathological form of cell death with an intracellular program mediated, which plays a pivotal role in maintaining homeostasis and embryonic development. Pyroptosis is a new paradigm of PCD, which has received increasing attention due to its close association with immunity and disease. Pyroptosis is a form of inflammatory cell death mediated by gasdermin that promotes the release of proinflammatory cytokines and contents induced by inflammasome activation. Recently, increasing evidence in studies shows that pyroptosis has a crucial role in inflammatory conditions like cardiovascular diseases (CVDs), cancer, neurological diseases (NDs), and metabolic diseases (MDs), suggesting that targeting cell death is a potential intervention for the treatment of these inflammatory diseases. Based on this, the review aims to identify the molecular mechanisms and signaling pathways related to pyroptosis activation and summarizes the current insights into the complicated relationship between pyroptosis and multiple human inflammatory diseases (CVDs, cancer, NDs, and MDs). We also discuss a promising novel strategy and method for treating these inflammatory diseases by targeting pyroptosis and focus on the pyroptosis pathway application in clinics. John Wiley and Sons Inc. 2023-04-25 /pmc/articles/PMC10130418/ /pubmed/37125240 http://dx.doi.org/10.1002/mco2.249 Text en © 2023 The Authors. MedComm published by Sichuan International Medical Exchange & Promotion Association (SCIMEA) and John Wiley & Sons Australia, Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Jin, Xiangyu Ma, Yinchu Liu, Didi Huang, Yi Role of pyroptosis in the pathogenesis and treatment of diseases |
title | Role of pyroptosis in the pathogenesis and treatment of diseases |
title_full | Role of pyroptosis in the pathogenesis and treatment of diseases |
title_fullStr | Role of pyroptosis in the pathogenesis and treatment of diseases |
title_full_unstemmed | Role of pyroptosis in the pathogenesis and treatment of diseases |
title_short | Role of pyroptosis in the pathogenesis and treatment of diseases |
title_sort | role of pyroptosis in the pathogenesis and treatment of diseases |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130418/ https://www.ncbi.nlm.nih.gov/pubmed/37125240 http://dx.doi.org/10.1002/mco2.249 |
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