Cargando…

Metrnl Alleviates Lipid Accumulation by Modulating Mitochondrial Homeostasis in Diabetic Nephropathy

Ectopic lipid accumulation in renal tubules is closely related to the pathogenesis of diabetic kidney disease (DKD), and mitochondrial dysfunction is thought to play a key role in lipid accumulation. Therefore, maintaining mitochondrial homeostasis holds considerable promise as a therapeutic strateg...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhou, Yuxia, Liu, Lu, Jin, Bangming, Wu, Yixuan, Xu, Lifen, Chang, Xuebing, Hu, Laying, Wang, Guifang, Huang, Yali, Song, Lingyu, Zhang, Tian, Wang, Yuanyuan, Xiao, Ying, Zhang, Fan, Shi, Mingjun, Liu, Lingling, Wang, Tuanlao, Yan, Rui, Guo, Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2023
Materias:	Pathophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130489/ https://www.ncbi.nlm.nih.gov/pubmed/36812572 http://dx.doi.org/10.2337/db22-0680

Ejemplares similares

The UDPase ENTPD5 regulates ER stress-associated renal injury by mediating protein N-glycosylation
por: Xu, Lifen, et al.
Publicado: (2023)

Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy
por: Zhang, Ming-Zhi, et al.
Publicado: (2012)

Epidermal Growth Factor Receptor Inhibition Slows Progression of Diabetic Nephropathy in Association With a Decrease in Endoplasmic Reticulum Stress and an Increase in Autophagy
por: Zhang, Ming-Zhi, et al.
Publicado: (2014)

TRB3 Gene Silencing Alleviates Diabetic Cardiomyopathy in a Type 2 Diabetic Rat Model
por: Ti, Yun, et al.
Publicado: (2011)

Pericyte Bridges in Homeostasis and Hyperglycemia
por: Corliss, Bruce A., et al.
Publicado: (2020)

Altered Calcium Homeostasis Does Not Explain the Contractile Deficit of Diabetic Cardiomyopathy
por: Zhang, Lin, et al.
Publicado: (2008)

Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight
por: Sisley, Stephanie R., et al.
Publicado: (2016)

Potential Role of Regulatory T Cells in Reversing Obesity-Linked Insulin Resistance and Diabetic Nephropathy
por: Eller, Kathrin, et al.
Publicado: (2011)

Endothelial METRNL determines circulating METRNL level and maintains endothelial function against atherosclerosis
por: Zheng, Sili, et al.
Publicado: (2023)

SGLT2 Deletion Improves Glucose Homeostasis and Preserves Pancreatic β-Cell Function
por: Jurczak, Michael J., et al.
Publicado: (2011)

Blockade of Endothelial-Mesenchymal Transition by a Smad3 Inhibitor Delays the Early Development of Streptozotocin-Induced Diabetic Nephropathy
por: Li, Jinhua, et al.
Publicado: (2010)

Protein Engineering Strategies for Sustained Glucagon-Like Peptide-1 Receptor–Dependent Control of Glucose Homeostasis
por: Picha, Kristen M., et al.
Publicado: (2008)

Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans
por: Xiao, Changting, et al.
Publicado: (2011)

Glycogen Synthase Kinase-3β Inhibition Ameliorates Cardiac Parasympathetic Dysfunction in Type 1 Diabetic Akita Mice
por: Zhang, Yali, et al.
Publicado: (2014)

Glucagon-Like Peptide 1 Recruits Microvasculature and Increases Glucose Use in Muscle via a Nitric Oxide–Dependent Mechanism
por: Chai, Weidong, et al.
Publicado: (2012)

Serum Metrnl is associated with the presence and severity of coronary artery disease
por: Liu, Zheng‐Xia, et al.
Publicado: (2018)

Angiotensin II Receptors Modulate Muscle Microvascular and Metabolic Responses to Insulin In Vivo
por: Chai, Weidong, et al.
Publicado: (2011)

Glucagon-Like Peptide 1 Recruits Muscle Microvasculature and Improves Insulin’s Metabolic Action in the Presence of Insulin Resistance
por: Chai, Weidong, et al.
Publicado: (2014)

Metrnl: a secreted protein with new emerging functions
por: Zheng, Si-li, et al.
Publicado: (2016)

Early Treatment of NOD Mice With B7-H4 Reduces the Incidence of Autoimmune Diabetes
por: Wang, Xiaojie, et al.
Publicado: (2011)

Cellular Stress, Excessive Apoptosis, and the Effect of Metformin in a Mouse Model of Type 2 Diabetic Embryopathy
por: Wu, Yanqing, et al.
Publicado: (2015)

Global Biochemical Profiling Identifies β-Hydroxypyruvate as a Potential Mediator of Type 2 Diabetes in Mice and Humans
por: Zhang, Sheng, et al.
Publicado: (2015)

A role of the adaptive immune system in glucose homeostasis
por: Bronsart, Laura L, et al.
Publicado: (2016)

F(1)F(0) ATP Synthase–Cyclophilin D Interaction Contributes to Diabetes-Induced Synaptic Dysfunction and Cognitive Decline
por: Yan, Shijun, et al.
Publicado: (2016)

Inflammation and Progressive Nephropathy in Type 1 Diabetes in the Diabetes Control and Complications Trial
por: Lin, Julie, et al.
Publicado: (2008)

Clinicopathological features of fast eGFR decliners among patients with diabetic nephropathy
por: Furuichi, Kengo, et al.
Publicado: (2020)

High Glucose–Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress
por: Gu, Hui, et al.
Publicado: (2016)

Urinary adiponectin as a new diagnostic index for chronic kidney disease due to diabetic nephropathy
por: Yamakado, Shinnosuke, et al.
Publicado: (2019)

White Matter Microstructural Change Contributes to Worse Cognitive Function in Patients With Type 2 Diabetes
por: Gao, Shudan, et al.
Publicado: (2019)

Serum Apolipoproteins Are Associated With Systemic and Retinal Microvascular Function in People With Diabetes
por: Sasongko, Muhammad Bayu, et al.
Publicado: (2012)

A Critical Role for the Type I Interferon Receptor in Virus-Induced Autoimmune Diabetes in Rats
por: Qaisar, Natasha, et al.
Publicado: (2017)

Risk Factors Related to Inflammation and Endothelial Dysfunction in the DCCT/EDIC Cohort and Their Relationship With Nephropathy and Macrovascular Complications
por: Lopes-Virella, Maria F., et al.
Publicado: (2008)

Coffee and Caffeine Consumption in Relation to Sex Hormone–Binding Globulin and Risk of Type 2 Diabetes in Postmenopausal Women
por: Goto, Atsushi, et al.
Publicado: (2011)

A High-Fat Diet Attenuates AMPK α1 in Adipocytes to Induce Exosome Shedding and Nonalcoholic Fatty Liver Development In Vivo
por: Yan, Chenghui, et al.
Publicado: (2021)

Lipoprotein Subfraction Cholesterol Distribution Is Proatherogenic in Women With Type 1 Diabetes and Insulin Resistance
por: Maahs, David M., et al.
Publicado: (2010)

Otopetrin 1 Protects Mice From Obesity-Associated Metabolic Dysfunction Through Attenuating Adipose Tissue Inflammation
por: Wang, Guo-Xiao, et al.
Publicado: (2014)

Insulin-Like Growth Factor Axis and Gestational Diabetes Mellitus: A Longitudinal Study in a Multiracial Cohort
por: Zhu, Yeyi, et al.
Publicado: (2016)

Brain Insulin Action Regulates Hypothalamic Glucose Sensing and the Counterregulatory Response to Hypoglycemia
por: Diggs-Andrews, Kelly A., et al.
Publicado: (2010)

Microscopic hematuria is a risk factor for end-stage kidney disease in patients with biopsy-proven diabetic nephropathy
por: Okada, Sadanori, et al.
Publicado: (2020)

Regulation of Mitochondrial Biogenesis by Lipoprotein Lipase in Muscle of Insulin-Resistant Offspring of Parents With Type 2 Diabetes
por: Morino, Katsutaro, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_32q8cirhs2rgdbp3a0fqlgrf65