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Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report

OBJECTIVE: To compare survival outcomes of type B radical hysterectomy (RH) and type C RH in patients with early-stage cervical cancer. METHODS: We retrospectively identified continuous cervical cancer patients with FIGO stage IA2-IB2 and IIA1 who underwent either type B RH (n = 278) or type C RH (n...

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Autores principales: Wang, Lu, Liu, Ping, Duan, Hui, Li, Pengfei, Su, Guidong, Li, Weili, Liang, Cong, Chen, Chunlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130524/
https://www.ncbi.nlm.nih.gov/pubmed/37123543
http://dx.doi.org/10.3389/fsurg.2023.1166084
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author Wang, Lu
Liu, Ping
Duan, Hui
Li, Pengfei
Su, Guidong
Li, Weili
Liang, Cong
Chen, Chunlin
author_facet Wang, Lu
Liu, Ping
Duan, Hui
Li, Pengfei
Su, Guidong
Li, Weili
Liang, Cong
Chen, Chunlin
author_sort Wang, Lu
collection PubMed
description OBJECTIVE: To compare survival outcomes of type B radical hysterectomy (RH) and type C RH in patients with early-stage cervical cancer. METHODS: We retrospectively identified continuous cervical cancer patients with FIGO stage IA2-IB2 and IIA1 who underwent either type B RH (n = 278) or type C RH (n = 148) performed by the same group of surgeons between 2009 and 2018. Propensity score matching was carried out to minimize selection biases. Intraoperative photographs, immediate postoperative questionnaire and specimen measurements were used to accurately determine the extensive of surgery. We further narrowed the study population to patients with specific histological subtypes and patients with deep stromal invasion. RESULTS: The median follow-up period was 42.41 ± 24.60 months. After adjusting, no differences in the 5-year overall survival (OS) and disease-free survival (DFS) were found between the type B group and the type C group (OS: 87.8% vs. 89.4%, P = 0.814; DFS: 84.9% vs. 85.6%, P = 0.898). In further analysis of patients with squamous-cell carcinoma, adenocarcinoma, adenosquamous carcinoma, similar 5-year OS and DFS rates were found between two groups (OS: 88.7% vs. 97.1%, P = 0.250; DFS: 84.7% vs. 92.3%, P = 0.541). Consistent results were found in patients with deep stromal invasion (OS: 81.8% vs. 100%, P = 0.144; DFS: 82.8% vs. 100%, P = 0.128). CONCLUSIONS: Type B RH could be used to treat FIGO stage IA2-IB2 and IIA1 cervical cancer to get equivalent 5-year OS and DFS. Further randomized controlled trials are warranted.
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spelling pubmed-101305242023-04-27 Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report Wang, Lu Liu, Ping Duan, Hui Li, Pengfei Su, Guidong Li, Weili Liang, Cong Chen, Chunlin Front Surg Surgery OBJECTIVE: To compare survival outcomes of type B radical hysterectomy (RH) and type C RH in patients with early-stage cervical cancer. METHODS: We retrospectively identified continuous cervical cancer patients with FIGO stage IA2-IB2 and IIA1 who underwent either type B RH (n = 278) or type C RH (n = 148) performed by the same group of surgeons between 2009 and 2018. Propensity score matching was carried out to minimize selection biases. Intraoperative photographs, immediate postoperative questionnaire and specimen measurements were used to accurately determine the extensive of surgery. We further narrowed the study population to patients with specific histological subtypes and patients with deep stromal invasion. RESULTS: The median follow-up period was 42.41 ± 24.60 months. After adjusting, no differences in the 5-year overall survival (OS) and disease-free survival (DFS) were found between the type B group and the type C group (OS: 87.8% vs. 89.4%, P = 0.814; DFS: 84.9% vs. 85.6%, P = 0.898). In further analysis of patients with squamous-cell carcinoma, adenocarcinoma, adenosquamous carcinoma, similar 5-year OS and DFS rates were found between two groups (OS: 88.7% vs. 97.1%, P = 0.250; DFS: 84.7% vs. 92.3%, P = 0.541). Consistent results were found in patients with deep stromal invasion (OS: 81.8% vs. 100%, P = 0.144; DFS: 82.8% vs. 100%, P = 0.128). CONCLUSIONS: Type B RH could be used to treat FIGO stage IA2-IB2 and IIA1 cervical cancer to get equivalent 5-year OS and DFS. Further randomized controlled trials are warranted. Frontiers Media S.A. 2023-04-12 /pmc/articles/PMC10130524/ /pubmed/37123543 http://dx.doi.org/10.3389/fsurg.2023.1166084 Text en © 2023 Wang, Liu, Duan, Li, Su, Li, Liang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Surgery
Wang, Lu
Liu, Ping
Duan, Hui
Li, Pengfei
Su, Guidong
Li, Weili
Liang, Cong
Chen, Chunlin
Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report
title Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report
title_full Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report
title_fullStr Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report
title_full_unstemmed Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report
title_short Abdominal type B vs. type C radical hysterectomy in early-stage cervical cancer: A matched single center cohort report
title_sort abdominal type b vs. type c radical hysterectomy in early-stage cervical cancer: a matched single center cohort report
topic Surgery
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130524/
https://www.ncbi.nlm.nih.gov/pubmed/37123543
http://dx.doi.org/10.3389/fsurg.2023.1166084
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