Long-term proliferation of immature hypoxia-dependent JMML cells supported by a 3D in vitro system

Juvenile myelomonocytic leukemia (JMML) is a rare clonal stem cell disorder that occurs in early childhood and is characterized by the hyperactivation of the RAS pathway in 95% of the patients. JMML is characterized by a hyperproliferation of granulocytes and monocytes, and little is known about the...

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Detalles Bibliográficos
Autores principales: Cani, Alice, Tretti Parenzan, Caterina, Frasson, Chiara, Rampazzo, Elena, Scarparo, Pamela, Francescato, Samuela, Caicci, Federico, Barbieri, Vito, Rosato, Antonio, Cesaro, Simone, Zecca, Marco, Micalizzi, Concetta, Sainati, Laura, Pigazzi, Martina, Biffi, Alessandra, Buldini, Barbara, Locatelli, Franco, Persano, Luca, Masetti, Riccardo, te Kronnie, Geertruij, Bresolin, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Myeloid Neoplasia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130612/
https://www.ncbi.nlm.nih.gov/pubmed/36053787
http://dx.doi.org/10.1182/bloodadvances.2021006746

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