Ferroptosis in diabetic nephropathy: Mechanisms and therapeutic implications

Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apopto...

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Detalles Bibliográficos
Autores principales: Mengstie, Misganaw Asmamaw, Seid, Mohammed Abdu, Gebeyehu, Natnael Atnafu, Adella, Getachew Asmare, Kassie, Gizchew Ambaw, Bayih, Wubet Alebachew, Gesese, Molalegn Mesele, Anley, Denekew Tenaw, Feleke, Sefineh Fenta, Zemene, Melkamu Aderajew, Dessie, Anteneh Mengist, Solomon, Yenealem, Bantie, Berihun, Dejenie, Tadesse Asmamaw, Teshome, Assefa Agegnehu, Abebe, Endeshaw Chekol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130620/
https://www.ncbi.nlm.nih.gov/pubmed/37124126
http://dx.doi.org/10.1016/j.metop.2023.100243
Descripción
Sumario:Diabetic Nephropathy (DN), the most common complication in diabetes mellitus, has been affecting the lives of people diabetic for a long time. Numerous studies have demonstrated the unbreakable connection between ferroptosis and kidney cell damage. Ferroptosis is a type of iron-dependent, non-apoptotic, regulated cell death, characterized by the buildup of intracellular lipid peroxides to lethal levels. Although the role of programmed cell deaths like apoptosis, autophagy, and necroptosis in the pathogenesis of DN has been demonstrated, the implication of ferroptosis in DN was least interrogated. Hence, the main aim of this review was to discuss the current understanding of ferroptosis focusing on its potential mechanisms, its involvement in DN, and emerging therapeutic opportunities.

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