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CD73, a significant protein in liver diseases
Purine adenosine pathway exists widely in the body metabolism, and is involved in regulating various physiological processes. It is one of the important pathways of environmental regulation in human body. CD73 is essentially a protease that catalyzes further dephosphorylation of extracellular adenin...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130655/ https://www.ncbi.nlm.nih.gov/pubmed/37122331 http://dx.doi.org/10.3389/fmed.2023.1147782 |
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author | Shi, Huilian Dai, Heng Sun, Qianqian Wang, Siliang Chen, Yuanyuan |
author_facet | Shi, Huilian Dai, Heng Sun, Qianqian Wang, Siliang Chen, Yuanyuan |
author_sort | Shi, Huilian |
collection | PubMed |
description | Purine adenosine pathway exists widely in the body metabolism, and is involved in regulating various physiological processes. It is one of the important pathways of environmental regulation in human body. CD73 is essentially a protease that catalyzes further dephosphorylation of extracellular adenine nucleotides, hydrolyzing extracellular AMP to adenosine and phosphate. CD73 is an important part of the adenosine signaling pathway. Studies have shown that CD73-mediated adenosine pathway can convert the inflammatory ATP into the immunosuppressant adenosine. This paper aims to summarize the relevant effects of CD73 in the occurrence, development and prognosis of liver diseases such as viral hepatitis, highlight the important role of CD73 in liver diseases, especially in viral hepatitis such as HBV and HCV, and explore new clinical ideas for future treatment targets of liver diseases. |
format | Online Article Text |
id | pubmed-10130655 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-101306552023-04-27 CD73, a significant protein in liver diseases Shi, Huilian Dai, Heng Sun, Qianqian Wang, Siliang Chen, Yuanyuan Front Med (Lausanne) Medicine Purine adenosine pathway exists widely in the body metabolism, and is involved in regulating various physiological processes. It is one of the important pathways of environmental regulation in human body. CD73 is essentially a protease that catalyzes further dephosphorylation of extracellular adenine nucleotides, hydrolyzing extracellular AMP to adenosine and phosphate. CD73 is an important part of the adenosine signaling pathway. Studies have shown that CD73-mediated adenosine pathway can convert the inflammatory ATP into the immunosuppressant adenosine. This paper aims to summarize the relevant effects of CD73 in the occurrence, development and prognosis of liver diseases such as viral hepatitis, highlight the important role of CD73 in liver diseases, especially in viral hepatitis such as HBV and HCV, and explore new clinical ideas for future treatment targets of liver diseases. Frontiers Media S.A. 2023-04-12 /pmc/articles/PMC10130655/ /pubmed/37122331 http://dx.doi.org/10.3389/fmed.2023.1147782 Text en Copyright © 2023 Shi, Dai, Sun, Wang and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Medicine Shi, Huilian Dai, Heng Sun, Qianqian Wang, Siliang Chen, Yuanyuan CD73, a significant protein in liver diseases |
title | CD73, a significant protein in liver diseases |
title_full | CD73, a significant protein in liver diseases |
title_fullStr | CD73, a significant protein in liver diseases |
title_full_unstemmed | CD73, a significant protein in liver diseases |
title_short | CD73, a significant protein in liver diseases |
title_sort | cd73, a significant protein in liver diseases |
topic | Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130655/ https://www.ncbi.nlm.nih.gov/pubmed/37122331 http://dx.doi.org/10.3389/fmed.2023.1147782 |
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