The motor domain of the kinesin Kip2 promotes microtubule polymerization at microtubule tips

Kinesins are microtubule-dependent motor proteins, some of which moonlight as microtubule polymerases, such as the yeast protein Kip2. Here, we show that the CLIP-170 ortholog Bik1 stabilizes Kip2 at microtubule ends where the motor domain of Kip2 promotes microtubule polymerization. Live-cell imagi...

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Detalles Bibliográficos
Autores principales: Chen, Xiuzhen, Portran, Didier, Widmer, Lukas A., Stangier, Marcel M., Czub, Mateusz P., Liakopoulos, Dimitris, Stelling, Jörg, Steinmetz, Michel O., Barral, Yves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130750/
https://www.ncbi.nlm.nih.gov/pubmed/37093124
http://dx.doi.org/10.1083/jcb.202110126

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