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Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts
OBJECTIVE: It is still a challenge to find a noninvasive technique to distinguish the histological subtypes of malignant pleural mesothelioma (MPM) and characterize the development of related histological features. We investigated the potential value of multiparametric MRI in the assessment of the h...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130770/ https://www.ncbi.nlm.nih.gov/pubmed/37123972 http://dx.doi.org/10.1016/j.heliyon.2023.e15237 |
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author | Zhang, Zhenghua Shen, Shasha Ma, Jiyao Qi, Tianfu Gao, Chao Hu, Xiong Han, Dan Huang, Yilong |
author_facet | Zhang, Zhenghua Shen, Shasha Ma, Jiyao Qi, Tianfu Gao, Chao Hu, Xiong Han, Dan Huang, Yilong |
author_sort | Zhang, Zhenghua |
collection | PubMed |
description | OBJECTIVE: It is still a challenge to find a noninvasive technique to distinguish the histological subtypes of malignant pleural mesothelioma (MPM) and characterize the development of related histological features. We investigated the potential value of multiparametric MRI in the assessment of the histological subtype and development of histologic features in the MPM xenograft model. METHODS: MPM xenograft models were developed by injecting tumour cells into the right axillary space of nude mice. The T1, T2, R2*, T2*, apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) at 14 d, 28 d, and 42 d were measured and compared between the epithelial and biphasic MPM. Correlations between multiparametric MRI parameters and histologic features, including necrotic fraction (NF) and microvessel density (MVD), were analysed. RESULTS: This study found that T2, T2* and IVIM-DWI parameters can reflect the spatial and temporal heterogeneity of MPM. Compared to the epithelial MPM, T2 and T2* were higher and ADC, D, D*, and f were lower in the biphasic MPM (P < 0.05). MRI parameters were different in different stages of epithelial and biphasic MPM. Moderate correlations were found between ADC and tumor volume and NF in the epithelial MPM, and there was a correlation between f and tumor volume and NF and MVD in the two groups. CONCLUSION: MRI parameters changed with tumor progression in a xenograft model of MPM. MRI parameters may provide useful biomarkers for evaluating the histological subtype and histological features development of MPM. |
format | Online Article Text |
id | pubmed-10130770 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier |
record_format | MEDLINE/PubMed |
spelling | pubmed-101307702023-04-27 Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts Zhang, Zhenghua Shen, Shasha Ma, Jiyao Qi, Tianfu Gao, Chao Hu, Xiong Han, Dan Huang, Yilong Heliyon Research Article OBJECTIVE: It is still a challenge to find a noninvasive technique to distinguish the histological subtypes of malignant pleural mesothelioma (MPM) and characterize the development of related histological features. We investigated the potential value of multiparametric MRI in the assessment of the histological subtype and development of histologic features in the MPM xenograft model. METHODS: MPM xenograft models were developed by injecting tumour cells into the right axillary space of nude mice. The T1, T2, R2*, T2*, apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo diffusion coefficient (D*), and perfusion fraction (f) at 14 d, 28 d, and 42 d were measured and compared between the epithelial and biphasic MPM. Correlations between multiparametric MRI parameters and histologic features, including necrotic fraction (NF) and microvessel density (MVD), were analysed. RESULTS: This study found that T2, T2* and IVIM-DWI parameters can reflect the spatial and temporal heterogeneity of MPM. Compared to the epithelial MPM, T2 and T2* were higher and ADC, D, D*, and f were lower in the biphasic MPM (P < 0.05). MRI parameters were different in different stages of epithelial and biphasic MPM. Moderate correlations were found between ADC and tumor volume and NF in the epithelial MPM, and there was a correlation between f and tumor volume and NF and MVD in the two groups. CONCLUSION: MRI parameters changed with tumor progression in a xenograft model of MPM. MRI parameters may provide useful biomarkers for evaluating the histological subtype and histological features development of MPM. Elsevier 2023-04-11 /pmc/articles/PMC10130770/ /pubmed/37123972 http://dx.doi.org/10.1016/j.heliyon.2023.e15237 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Research Article Zhang, Zhenghua Shen, Shasha Ma, Jiyao Qi, Tianfu Gao, Chao Hu, Xiong Han, Dan Huang, Yilong Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
title | Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
title_full | Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
title_fullStr | Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
title_full_unstemmed | Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
title_short | Sequential multi-parametric MRI in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
title_sort | sequential multi-parametric mri in assessment of the histological subtype and features in the malignant pleural mesothelioma xenografts |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130770/ https://www.ncbi.nlm.nih.gov/pubmed/37123972 http://dx.doi.org/10.1016/j.heliyon.2023.e15237 |
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