Cargando…
NDC80 status pinpoints mitotic kinase inhibitors as emerging therapeutic options in clear cell renal cell carcinoma
∼30% of clear cell renal cell carcinoma (ccRCC) patients present with metastatic disease at the time of diagnosis, causing a dire 5-year survival rate of 13%. Although anti-PD-1 immunotherapy has improved survival, a strong need remains for new therapeutic options. Using integrated network analysis,...
Autores principales: | Hu, Cheng, Lin, Weiming, Zhao, Kemeng, Tian, Guiyou, Kong, Xiangquan, Luo, Guangcheng, Wolf, Dieter A., Cheng, Yabin |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10130926/ https://www.ncbi.nlm.nih.gov/pubmed/37123230 http://dx.doi.org/10.1016/j.isci.2023.106531 |
Ejemplares similares
-
The Ndc80 complex targets Bod1 to human mitotic kinetochores
por: Schleicher, Katharina, et al.
Publicado: (2017) -
Stable kinetochore‐microtubule attachment requires loop‐dependent Ndc80‐Ndc80 binding
por: Polley, Soumitra, et al.
Publicado: (2023) -
VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro
por: Laine, Leena J., et al.
Publicado: (2021) -
Effect of NDC80 in human hepatocellular carcinoma
por: Ju, Lin-Ling, et al.
Publicado: (2017) -
MAPping the Ndc80 loop in cancer: A possible link between Ndc80/Hec1 overproduction and cancer formation
por: Tang, Ngang Heok, et al.
Publicado: (2015)